Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Arteriosclerosis, Thrombosis, and Vascular Biology. 1984;4:103-114

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bates, S. R.
Right arrow Articles by Getz, G. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bates, S. R.
Right arrow Articles by Getz, G. S.

Arteriosclerosis, Vol 4, 103-114, Copyright © 1984 by American Heart Association

ARTICLES

Very low density lipoproteins promote triglyceride accumulation in macrophages

SR Bates, PL Murphy, ZC Feng, T Kanazawa and GS Getz

Incubation of mouse peritoneal macrophages with very low density lipoproteins (VLDL) from normal rats or rhesus monkeys markedly increased the levels of intracellular triglycerides by 10- to 56-fold and was accompanied by the production of oil red O positive vacuoles. The stimulation of triglyceride accumulation in macrophages was time- and concentration-dependent and was specific for VLDL. Three possible mechanisms for the VLDL-stimulated triglyceride accumulation in macrophages were explored: receptor-mediated uptake, action of lipoprotein lipase, and phagocytosis. Macrophage uptake and degradation of 125I-monkey and rat VLDL demonstrated saturable and nonsaturable components. Uptake of 125I-VLDL could be inhibited by unlabeled normal VLDL, although hyperlipemic VLDL was more effective. HDL did not compete to a significant extent. Heparin released lipoprotein lipase- like activity from peritoneal macrophages. Addition of heparin with VLDL resulted in a greater, more rapid elevation in intracellular triglycerides, which was partially inhibited by albumin. Free fatty acid and Intralipid also produced triglyceride accumulation in macrophages. The data showed that all three of the mechanisms examined could contribute to the metabolism of VLDL by macrophages and cause the production of triglyceride-rich cells with a "foamy" appearance, although the evidence suggested that the action of lipoprotein lipase was probably the most important in this process.


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
V. Saraswathi and A. H. Hasty
Inhibition of Long-Chain Acyl Coenzyme A Synthetases During Fatty Acid Loading Induces Lipotoxicity in Macrophages
Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1937 - 1943.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
J. C. Ullery-Ricewick, B. E. Cox, E. E. Griffin, and W. G. Jerome
Triglyceride alters lysosomal cholesterol ester metabolism in cholesteryl ester-laden macrophage foam cells
J. Lipid Res., October 1, 2009; 50(10): 2014 - 2026.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
V. Saraswathi and A. H. Hasty
The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages
J. Lipid Res., July 1, 2006; 47(7): 1406 - 1415.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Cancello, C. Henegar, N. Viguerie, S. Taleb, C. Poitou, C. Rouault, M. Coupaye, V. Pelloux, D. Hugol, J.-L. Bouillot, et al.
Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss
Diabetes, August 1, 2005; 54(8): 2277 - 2286.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. T. Lada, M. C. Willingham, and R. W. St. Clair
Triglyceride depletion in THP-1 cells alters cholesteryl ester physical state and cholesterol efflux
J. Lipid Res., April 1, 2002; 43(4): 618 - 628.
[Abstract] [Full Text] [PDF]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1984 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.