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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:983.)
© 2009 American Heart Association, Inc.

Brief Reviews

Molecular Imaging in Atherosclerosis, Thrombosis, and Vascular Inflammation

Robin P. Choudhury; Edward A. Fisher

From the Department of Cardiovascular Medicine (R.P.C.), University of Oxford, UK; and New York University School of Medicine (E.A.F.), New York.

Correspondence to Dr Robin Choudhury, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford. OX3 9DU, UK. E-mail robin.choudhury{at}cardiov.ox.ac.uk

Series Editor: Zahi Fayad
ATVB In Focus

Molecular Imaging of Cardiovascular Disease

Appreciation of the molecular and cellular processes of atherosclerosis, thrombosis, and vascular inflammation has identified new targets for imaging. The common goals of molecular imaging approaches are to accelerate and refine diagnosis, provide insights that reveal disease diversity, guide specific therapies, and monitor the effects of those therapies. Here we undertake a comparative analysis of imaging modalities that have been used in this disease area. We consider the elements of contrast agents, emphasizing how an understanding of the biology of atherosclerosis and its complications can inform optimal design. We address the potential and limitations of current contrast approaches in respect of translation to clinically usable agents and speculate on future applications.

Key Words: atherosclerosis • inflammation • molecular imaging

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