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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:1144.)
© 2009 American Heart Association, Inc.

Clinical and Population Studies

Serum Resistin Concentrations and Risk of New Onset Heart Failure in Older Persons

The Health, Aging, and Body Composition (Health ABC) Study

Javed Butler; Andreas Kalogeropoulos; Vasiliki Georgiopoulou; Nathalie de Rekeneire; Nicolas Rodondi; Andrew L. Smith; Udo Hoffmann; Alka Kanaya; Anne B. Newman; Stephen B. Kritchevsky; Ramachandran S. Vasan; Peter W.F. Wilson; Tamara B. Harris for the Health ABC Study

From Emory University (J.B., A.K., V.G., A.L.S., P.W.F.W.), Atlanta Ga; Epicenter (N.d.R.), Paris, France; the University of Lausanne (N.R.), Switzerland; Massachusetts General Hospital (U.H.), Harvard Medical School, Boston Mass; University of California San Francisco (A.K.); University of Pittsburgh (A.B.N.), Pa; Wake Forest University (S.B.K.), Winston Salem NC; Boston University School of Medicine (R.S.V.), Mass; and the Intramural Research Program (T.B.H.), National Institute of Aging, National Institutes of Health, Bethesda, Md.

Correspondence to Javed Butler, MD, MPH, Cardiology Division, Emory University Hospital, 1365 Clifton Road NE, Suite AT 430, Atlanta GA 30322. E-mail javed.butler{at}emory.edu

Objective— Resistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction. We investigated the association of serum resistin concentrations with risk for incident heart failure (HF) in humans.

Methods and Results— We studied 2902 older persons without prevalent HF (age, 73.6±2.9 years; 48.1% men; 58.8% white) enrolled in the Health, Aging, and Body Composition (Health ABC) Study. Correlation between baseline serum resistin concentrations (20.3±10.0 ng/mL) and clinical variables, biochemistry panel, markers of inflammation and insulin resistance, adipocytokines, and measures of adiposity was weak (all rho <0.25). During a median follow-up of 9.4 years, 341 participants (11.8%) developed HF. Resistin was strongly associated with risk for incident HF in Cox proportional hazards models controlling for clinical variables, biomarkers, and measures of adiposity (HR, 1.15 per 10.0 ng/mL in adjusted model; 95% CI, 1.05 to 1.27; P=0.003). Results were comparable across sex, race, diabetes mellitus, and prevalent and incident coronary heart disease subgroups. In participants with available left ventricular ejection fraction at HF diagnosis (265 of 341; 77.7%), association of resistin with HF risk was comparable for cases with reduced versus preserved ejection fraction.

Conclusions— Serum resistin concentrations are independently associated with risk for incident HF in older persons.

In 2902 older persons, baseline serum resistin concentrations (20.3±10.0 ng/mL) were strongly associated with risk for new onset heart failure. This association persisted after controlling for baseline characteristics, clinical predictors of incident heart failure, markers of inflammation and insulin resistance, and adiposity measures (HR, 1.15 per 10.0 ng/mL in adjusted model; 95%CI, 1.05 to 1.27; P=0.003).

Key Words: heart failure • elderly • resistin

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