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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:1017.)
© 2009 American Heart Association, Inc.

Brief Reviews

Optical and Multimodality Molecular Imaging

Insights Into Atherosclerosis

Farouc A. Jaffer; Peter Libby; Ralph Weissleder

From the Cardiovascular Research Center and Cardiology Division (F.A.J.), the Center for Molecular Imaging Research (F.A.J., R.W.), and the Center for Systems Biology (R.W.), Massachusetts General Hospital; the Cardiovascular Division (P.L.), Brigham and Women’s Hospital, Boston, Mass, and the Donald W. Reynolds Cardiovascular Clinical Research Center (F.A.J., P.L., R.W.), Harvard Medical School.

Correspondence to Farouc Jaffer, MGH CVRC, Simches Research Building, Room 3206, 185 Cambridge Street, Boston, MA 02114. E-mail fjaffer{at}mgh.harvard.edu

Series Editor: Zahi Fayad
ATVB In Focus

Molecular Imaging of Cardiovascular Disease

Imaging approaches that visualize molecular targets rather than anatomic structures aim to illuminate vital molecular and cellular aspects of atherosclerosis biology in vivo. Several such molecular imaging strategies stand ready for rapid clinical application. This review describes the growing role of in vivo optical molecular imaging in atherosclerosis and highlights its ability to visualize atheroma inflammation, calcification, and angiogenesis. In addition, we discuss advances in multimodality probes, both in the context of multimodal imaging as well as multifunctional, or "theranostic," nanoparticles. This review highlights particular molecular imaging strategies that possess strong potential for clinical translation.

Key Words: atherosclerosis • molecular imaging • optical • fluorescence • multimodality • nanoparticle

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