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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:792.)
© 2009 American Heart Association, Inc.

Editorial

Some Things Just Have to Be Done In Vivo

GPIHBP1, Caloric Delivery, and the Generation of Remnant Lipoproteins

Kevin Jon Williams

From the Section of Endocrinology, Diabetes, and Metabolism, Temple University School of Medicine, Philadelphia, Pa.

Correspondence to Kevin Jon Williams, MD, Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, 3322 North Broad Street, Medical Office Building, Room 212, Philadelphia, PA 19140. E-mail K_Williams{at}mail.jci.tju.edu

The recent discovery of a dysfunctional mutation of GPIHBP1 in a man with chylomicronemia implicates this protein in human physiology. GPIHBP1 can be placed in the larger context of other molecular participants in chylomicron docking and hydrolysis on microvascular endothelium, caloric delivery, and remnant lipoprotein generation. Critical questions include the regulation—and dysregulation—of these processes in states of overnutrition, underexertion, obesity, insulin resistance, and diabetes.

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Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase

Anne P. Beigneux, Remco Franssen, André Bensadoun, Peter Gin, Kristan Melford, Jorge Peter, Rosemary L. Walzem, Michael M. Weinstein, Brandon S.J. Davies, Jan A. Kuivenhoven, John J.P. Kastelein, Loren G. Fong, Geesje M. Dallinga-Thie, and Stephen G. Young
Arterioscler Thromb Vasc Biol 2009 29: 956-962. [Abstract] [Full Text] [PDF]