This Article Full Text Full Text (PDF) All Versions of this Article: 29/6/789    most recent ATVBAHA.108.179663v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Google Scholar Articles by Ferrara, N. PubMed PubMed Citation Articles by Ferrara, N. Related Collections History of Discovery

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:789.)
© 2009 American Heart Association, Inc.

History of Discovery

Vascular Endothelial Growth Factor

Napoleone Ferrara

From Genentech Inc, San Francisco, Calif.

Correspondence to Napoleone Ferrara, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080. E-mail nf{at}gene.com

Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.

This article has been cited by other articles:

				J. W. Holaday and B. A. Berkowitz Antiangiogenic Drugs: Insights into Drug Development from Endostatin, Avastin and Thalidomide Mol. Interv., August 1, 2009; 9(4): 157 - 166. [Full Text] [PDF]