This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jang, M. J. Articles by Oh, D. Search for Related Content PubMed PubMed Citation Articles by Jang, M. J. Articles by Oh, D. Related Collections Venous Thromboembolism

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:311.)
© 2009 American Heart Association, Inc.

Venous Thromboembolism: Mechanisms, Treatment, and Public Awareness

Metabolic Syndrome Is Associated With Venous Thromboembolism in the Korean Population

Moon Ju Jang; Won-il Choi; Soo-Mee Bang; Taeseung Lee; Yeo-Kyeoung Kim; Walter Ageno; Doyeun Oh

From the Department of Internal Medicine (M.J.J., D.O.), College of Medicine, Pochon CHA University, Sungnam, Korea; the Department of Internal Medicine (W.C.), College of Medicine, Keymyung University, Daegu, Korea; the Department of Internal Medicine (S.-M.), Seoul National University Bundang Hospital, Sungnam, Korea; the Department of Vascular Surgery (T.L.), Seoul National University Bundang Hospital, Sungnam, Korea; the Department of Internal Medicine (Y.-K.K.), College of Medicine, Chonnam National University, Kwangju, Korea; and the Department of Clinical Medicine (W.A.), University of Insubria, Varese, Italy.

Correspondence to Doyeun Oh, Department of Internal Medicine, College of Medicine, Pochon CHA University, Sungnam, Korea. E-mail dohl{at}cha.ac.kr or Walter Ageno, U.O. Medicinal Ospedale di Circolo, Vale Borri 57, 21100 Varese, Italy. E-mail agewal@yahoo.com

Background— The metabolic syndrome (MS) is a known risk factor for arterial thromboembolism. Preliminary reports have also suggested the association between MS and venous thromboembolism (VTE).

Methods and Results— In this case–control study, we investigated the association between MS and VTE in Korean patients. Patients with objectively diagnosed VTE and healthy control subjects underwent clinical assessment for the presence of MS according to the National Cholesterol Education Adult Treatment Panel III criteria modified with body mass index (WHO Asian Pacific Perspective, 2000). The presence of known risk factors for VTE was ascertained. Patients with VTE secondary to cancer were excluded. The prevalence of MS was compared between VTE group and controls. Two hundred eight VTE patients and 300 controls were assessed. VTE was idiopathic in 91 patients and secondary to a known risk factor in 117. The prevalence of MS was significantly higher in VTE patients (47.6%) than in controls (37.7%) (OR: 1.50; 95% CI: 1.05 to 2.15, P=0.026). After adjusting for age, sex, and smoking status, metabolic MS remained independently associated with VTE (OR: 1.56; 95% CI: 1.07 to 2.27, P=0.020). In the subgroup analysis, MS was also independently associated with idiopathic VTE (OR: 1.71; 95% CI: 1.04 to 2.81, P=0.033), but not with secondary VTE (OR: 1.43; 95% CI: 0.91 to 2.99, P=0.121). Multivariate analysis demonstrated that high BMI (OR: 1.70, 95% CI: 1.01 to 2.87), decreased HDL cholesterol (OR: 1.99, 95% CI: 1.17 to 3.39), and elevated fasting glucose levels (OR: 2.31; 95% CI: 1.35 to 3.94) were associated with idiopathic VTE.

Conclusion— MS is associated with VTE and in particular with idiopathic VTE in the Korean population.

Key Words: venous thromboembolism metabolic syndrome

This article has been cited by other articles:

				A. S. Wolberg and N. Mackman Venous Thromboembolism: Risk Factors, Biomarkers, and Treatment Arterioscler Thromb Vasc Biol, March 1, 2009; 29(3): 296 - 297. [Full Text] [PDF]