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Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:284-288
Published online before print February 16, 2009, doi: 10.1161/ATVBAHA.108.179788
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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:284.)
© 2009 American Heart Association, Inc.

Go Red for Women

Thrombosis and Antithrombotic Therapy in Women

Alison L. Bailey; Dawn C. Scantlebury; Susan S. Smyth

From the Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, VA Medical Center, Lexington.

Correspondence to Susan S. Smyth, 326 Charles T Wethington Building, 900 S Limestone, Lexington, KY 40536-0200. E-mail SusanSmyth{at}uky.edu

Sex-based differences in the prevalence and presentation of arterial and venous thrombosis exist, and emerging data indicate that men and women do not accrue equal benefit from antithrombotic therapy. Sex hormones alter procoagulant protein expression and the function of blood and vascular cells. Sex-based differences in platelet function have been reported, and in animal models, sex-based differences in thrombosis have been noted. Here we review plausible mechanisms that may explain how sex functions as a modifier of thrombosis and summarize clinical data on the interaction between sex and response to antithrombotic therapy.


Key Words: anti-thrombotic therapy • female • platelet • thrombosis


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