This Article Full Text Full Text (PDF) All Versions of this Article: 29/10/1439    most recent ATVBAHA.108.175240v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Google Scholar Articles by Daum, G. Articles by Reidy, M.A. PubMed PubMed Citation Articles by Daum, G. Articles by Reidy, M.A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Related Collections Related Article

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:1439.)
© 2009 American Heart Association, Inc.

Brief Reviews

Sphingosine 1-Phosphate

A Regulator of Arterial Lesions

G. Daum; A. Grabski; M.A. Reidy

From the Departments of Surgery (G.D., A.G.) and Pathology (A.G., M.A.R.), University of Washington, Seattle.

Correspondence to M.A. Reidy. E-mail mar1{at}u.washington.edu

Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid that is critical in the development of blood vessels, and in the adult regulates vascular functions including vascular tone, endothelial integrity, and angiogenesis. Further, S1P may regulate arterial lesions in disease and after injury by controlling leukocyte recruitment and smooth muscle cell functions.

Related Article:

Sphingosine-1-Phosphate Receptor-2 Regulates Expression of Smooth Muscle Alpha-Actin After Arterial Injury

Allison D. Grabski, Takuya Shimizu, Jessie Deou, William M. Mahoney, Jr, Michael A. Reidy, and Guenter Daum
Arterioscler Thromb Vasc Biol 2009 29: 1644-1650. [Abstract] [Full Text] [PDF]