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Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:s5-s10
Published online before print January 3, 2008, doi: 10.1161/ATVBAHA.107.158915
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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:s5.)
© 2008 American Heart Association, Inc.

Translational Therapeutics at the Platelet Vascular Interface: A CME-Certified Activity

Platelets: Inflammatory Firebugs of Vascular Walls

Andreas E. May; Peter Seizer; Meinrad Gawaz

From the Medizinische Klinik III, Eberhard Karls Universität Tübingen, Germany.

Correspondence to Andreas E. May, MD, Medizinische Klinik III, Eberhard Karls Universität Tübingen, Otfried-Müller-Strasse 10, D-72076 Tübingen, Germany. E-mail andreas.may{at}med.uni-tuebingen.de

Atherosclerosis is an inflammatory disease. Platelets can "inflame" the vascular wall by various mechanisms and thereby initiate and support the development of atherosclerosis. Platelet interaction with leukocytes, endothelial cells, and circulating progenitor cells triggers autocrine and paracrine activation processes, leading to inflammatory and atherogenic cascades at the vascular wall. This review highlights the molecular key components and pathways used by platelets to trigger and accelerate inflammation at the vascular wall and, thereby, atherosclerosis.


Key Words: platelets • atherosclerosis • inflammation • vasculature • cardiovascular events




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