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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:s11.)
© 2008 American Heart Association, Inc.

Translational Therapeutics at the Platelet Vascular Interface: A CME-Certified Activity

Oxidative Stress and Platelets

Jane E. Freedman

From the Boston University School of Medicine, Mass.

Correspondence to Jane E. Freedman, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118. E-mail freedmaj{at}bu.edu

Abstract

Platelet-dependent thrombus formation may be influenced by alteration of platelet or vascular redox state, the presence of endogenous or exogenous antioxidants, as well as the formation of reactive oxygen and nitrogen species. Specifically, settings and pathways that influence the formation of superoxide and nitric oxide, as well as their metabolism, may influence platelet function and thrombus formation. Although some antioxidant regimens have been associated with bleeding and hemorrhagic stroke, the therapeutic value of antioxidants in clinical syndromes that lead to platelet-dependent thrombosis is not clear, as supplemental antioxidants have not been generally associated with better cardiovascular outcome.

Key Words: platelet • antioxidant • thrombosis • redox