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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:2085.)
© 2008 American Heart Association, Inc.

Clinical and Population Studies

Associations Between Single Nucleotide Polymorphisms on Chromosome 9p21 and Risk of Coronary Heart Disease in Chinese Han Population

Li Zhou; Xiaomin Zhang; Mei'an He; Longxian Cheng; Ying Chen; Frank B. Hu; Tangchun Wu

From the Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health, School of Public Health (L.Z., X.Z., M.H., T.W.); the Department of Cardiology, Union Hospital, (L.C., Y.C.), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; and the Departments of Nutrition and Epidemiology (F.B.H), Harvard School of Public Health, Boston, Mass.

Correspondence to Tangchun Wu, MD, PhD, Institute of Occupational Medicine, School of Public Health, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, Hubei 430030, China. E-mail wut{at}mails.tjmu.edu.cn and Frank B Hu, MD, PhD, Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA. E-mail: frank.hu@channing.harvard.edu

Objectives— We aimed to determine whether the single nucleotide polymorphisms (SNPs) on chromosome 9p21 were associated with coronary heart disease (CHD) in a Chinese Han population.

Methods and Results— We determined the genotypes of rs2383206 and rs2383207 on chromosome 9p21 in 1360 CHD patients and 1360 age- and sex-frequency–matched controls from an unrelated Chinese Han population. GG genotypes in rs2383207 occurred more frequently in CHD patients compared to controls, and the odds ratio (OR) was 1.52 (95% CI 1.13 to 2.04), after adjusting for conventional risk factors. In stratified analysis, the risk associated with the GG genotype of the two SNPs was stronger in subjects who were males, less than 60 years old, overweight, and smokers. The SNP rs2383207 had significant interactions with gender and smoking (P=0.018 and 0.037, respectively). The risk allele G of rs2383207 plus family history of CHD had a cumulative association with CHD (P for trend, 1.0x10^–6); the OR for CHD was 4.59 (95% CI 2.52 to 8.37) for those with all the risk factors as compared with subjects without any of the factors.

Conclusions— The SNP rs2383207 on chromosome 9p21 is significantly associated with CHD in Chinese. This SNP combined with family history has a cumulative association with CHD.

We determined genotypes of rs2383206 and rs2383207 on chromosome 9p21 in 1360 CHD patients and matched controls. Our results indicate that rs2383207 is significantly associated with higher risk of CHD in a Chinese Han population. The risk allele of rs2383207 plus a family history have a cumulative association with CHD.

Key Words: coronary heart disease • single nucleotide polymorphism • family history • genetic variation • risk factor