Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:1928-1936
Published online before print August 28, 2008, doi: 10.1161/ATVBAHA.108.162925
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
28/11/1928    most recent
ATVBAHA.108.162925v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Keeley, E. C.
Right arrow Articles by Strieter, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Keeley, E. C.
Right arrow Articles by Strieter, R. M.
Related Collections
Right arrow Angiogenesis
Right arrow Chemokines in ATVB
(Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:1928.)
© 2008 American Heart Association, Inc.

Brief Reviews

Chemokines as Mediators of Neovascularization

Ellen C. Keeley; Borna Mehrad; Robert M. Strieter

From the Department of Medicine, Divisions of Cardiology (E.C.K.) and Pulmonary and Critical Care Medicine (B.M., R.M.S.), University of Virginia, Charlottesville.

Correspondence to Robert M. Strieter, MD, University of Virginia, Department of Medicine, Division of Pulmonary Critical Care, Box 800466, Charlottesville, VA 22908-0466. E-mail Strieter{at}Virginia.edu

Series Editor: Christian Weber
ATVB In Focus

Chemokines in Atherosclerosis, Thrombosis, and Vascular Biology

Chemokines are a superfamily of homologous heparin-binding proteins, first described for their role in recruiting leukocytes to sites of inflammation. Chemokines have since been recognized as key factors mediating both physiological and pathological neovascularization in such diverse clinical settings as malignancy, wound repair, chronic fibroproliferative disorders, myocardial ischemia, and atherosclerosis. Members of the CXC chemokine family, structurally defined as containing the ELR amino acid motif, are potent inducers of angiogenesis, whereas another subset of the CXC chemokines inhibits angiogenesis. In addition, CCL2, a CC chemokine ligand, has been implicated in arteriogenesis. In this article, we review the current literature on the role of chemokines as mediators of neovascularization.


Key Words: angiogenesis • cytokines • arteriogenesis • chemokines






ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 2008 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.