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Brief Reviews |
From the Department of Molecular Cell Biology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.
Correspondence to Peter L. Hordijk, Sanquin Research, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands. E-mail p.hordijk{at}sanquin.nl
Series Editor: Dietmar Vestweber
Vascular Adhesion Molecules
ATVB In Focus
Previous Brief Reviews in this Series:
Vestweber D. Vascular adhesion molecules. Arterioscler Thromb Vasc Biol. 2007;27:1869.
The migration of leukocytes across the endothelial lining of the vascular wall requires a complicated series of adhesion and signaling events. Endothelial Ig-like cell adhesion molecules (IgCAMs) such as intercellular adhesion molecule-1 play an important role, not only as ligands for leukocyte integrins, but also as signaling initiators. Clustering these IgCAMs triggers a wide range of events in the endothelial cells interior, of which activation of Rho-like GTPases, induction of cytoskeletal changes, and the transient modulation of cell-cell contact are key events. This review discusses recent insights into this IgCAM-driven endothelial signaling and its consequences for leukocyte transendothelial migration.
Migration of leukocytes across the endothelial lining of the vasculature requires a complicated series of adhesion and signaling events, in which endothelial Ig-like cell adhesion molecules (IgCAMs) play an important role. This review discusses recent insights into this IgCAM-driven endothelial signaling and its consequences for leukocyte transendothelial migration.
Key Words: ICAM-1 VCAM-1 transendothelial migration signaling Rho GTPases
Related Article:
Arterioscler. Thromb. Vasc. Biol. 2007 27: 1869.
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