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Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:1870-1876
Published online before print June 21, 2007, doi: 10.1161/ATVBAHA.107.145821
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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:1870.)
© 2007 American Heart Association, Inc.

Brief Reviews

Endothelial Signaling by Ig-Like Cell Adhesion Molecules

Jaap D. van Buul; Edwin Kanters; Peter L. Hordijk

From the Department of Molecular Cell Biology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.

Correspondence to Peter L. Hordijk, Sanquin Research, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands. E-mail p.hordijk{at}sanquin.nl

Series Editor: Dietmar Vestweber
Vascular Adhesion Molecules
ATVB In Focus

Previous Brief Reviews in this Series:

•Vestweber D. Vascular adhesion molecules. Arterioscler Thromb Vasc Biol. 2007;27:1869.

The migration of leukocytes across the endothelial lining of the vascular wall requires a complicated series of adhesion and signaling events. Endothelial Ig-like cell adhesion molecules (IgCAMs) such as intercellular adhesion molecule-1 play an important role, not only as ligands for leukocyte integrins, but also as signaling initiators. Clustering these IgCAMs triggers a wide range of events in the endothelial cells’ interior, of which activation of Rho-like GTPases, induction of cytoskeletal changes, and the transient modulation of cell-cell contact are key events. This review discusses recent insights into this IgCAM-driven endothelial signaling and its consequences for leukocyte transendothelial migration.

Migration of leukocytes across the endothelial lining of the vasculature requires a complicated series of adhesion and signaling events, in which endothelial Ig-like cell adhesion molecules (IgCAMs) play an important role. This review discusses recent insights into this IgCAM-driven endothelial signaling and its consequences for leukocyte transendothelial migration.


Key Words: ICAM-1 • VCAM-1 • transendothelial migration • signaling • Rho GTPases


Related Article:

Vascular Adhesion Molecules
Dietmar Vestweber
Arterioscler. Thromb. Vasc. Biol. 2007 27: 1869. [Full Text] [PDF]





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