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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:2284.)
© 2007 American Heart Association, Inc.

Brief Reviews

Links Between Adipose Tissue and Thrombosis in the Mouse

Peter F. Bodary

From the Department of Nutrition and Food Science, College of Liberal Arts and Sciences, Wayne State University, Detroit, Mich.

Correspondence to Peter F. Bodary, PhD, 410 W. Warren Ave, 3009 Science Hall, Detroit, MI 48202. E-mail pfbodary{at}wayne.edu

Series Editor: Daniel T. Eitzman Previous Brief Reviews in this Series:

•Tollefsen D. Heparin cofactor II modulates the response to vascular injury. 2007;27:454–460.
•Denis CV and Wagner DD. Platelet adhesion receptors and their ligands in mouse models of thrombosis. 2007;27:728–739.
•Fay WP, Garg N, and Sunkar M. Vascular function of the plasminogen activation system. 2007;27:1231–1237.
•Desch KC and Motto DG. Thrombotic thrombocytopenic purpura in humans and mice. 2007;27:1901–1908.
•Westrick R, Winn ME, and Eitzman DT. Murine models of vascular thrombosis. 2007;27:2079–2093.

Obesity has become a global epidemic and carries a considerable negative impact in regard to quality of life and life expectancy. A primary problem is that obese individuals are at increased risk of suffering from cardiovascular disease complications such as myocardial infarction and stroke. Because fat accumulation is a consistent aspect of obesity, mechanisms that may link adipose tissue to cardiovascular disease complications should be considered. Proteins expressed from adipose tissue, known as adipokines, are hypothesized to have important effects on the progression and incidence of cardiovascular disease complications. This review examines the evidence that adipokines play a direct role in vascular thrombosis, an important event in cardiovascular disease complications.

Obese individuals have an altered hemostatic profile which favors blood clot formation and thrombosis. To investigate the potential relationship between arterial thrombosis and adipose-derived proteins, mouse models of thrombosis have been used. This review examines the evidence that adipokines have a direct effect on arterial thrombosis.

Key Words: hemostasis • coagulation • obesity • diabetes