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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:1948.)
© 2006 American Heart Association, Inc.

Brief Reviews

Angiogenesis in Atherogenesis

Joerg Herrmann; Lilach O. Lerman; Debabrata Mukhopadhyay; Claudio Napoli; Amir Lerman

From the Division of Cardiovascular Diseases (J.H., A.L.), Division of Nephrology and Hypertension (L.O.L.), and Division of Biochemistry and Molecular Biology (D.M.), Mayo Clinic, Rochester, Minn; Department of General Pathology (C.N.), Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Naples, Italy.

Correspondence to Amir Lerman, Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905. E-mail lerman.amir{at}mayo.edu

Atherogenesis is the pathobiological process, which underlies atherosclerotic cardiovascular disease and evolves in the 3 stages of initiation, progression, and complication to clinical significance. Of note, this process is associated with neovascularization, and it was not until recently that the implications of angiogenesis in atherogenesis were delineated. This article gives an updated overview on this topic and briefly reflects on the similarities with neovessel formation in carcinogenesis.

Atherogenesis is the pathobiological process, which underlies atherosclerotic cardiovascular disease and evolves in the 3 stages of initiation, progression, and complication to clinical significance. Of note, this process is associated with neovascularization, and it was not until recently that the implications of angiogenesis in atherogenesis were delineated. This article gives an updated overview on this topic and briefly reflects on the similarities with neovessel formation in carcinogenesis.

Key Words: atherosclerosis • cancer • neovascularization • oxidative stress • pathology

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