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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:1936.)
© 2006 American Heart Association, Inc.

Brief Reviews

Transcriptional Regulators of Angiogenesis

Anne Hamik; Baiqiu Wang; Mukesh K. Jain

From the Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass.

Correspondence to Mukesh K. Jain, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115. E-mail mjain{at}rics.bwh.harvard.edu

Series Editor: Stephanie Dimmeler
Novel Mediators and Mechanisms in Angiogenesis and Vasculogenesis
ATVB In Focus

Previous Brief Reviews in this Series:

•Ferguson JE III, Kelley RW, Patterson C. Mechanisms of endothelial differentiation in embryonic vasculogenesis. 2005;25:2245–2254.
•Werner N, Nickenig G. Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy? 2006;26:257–266.
•van Hinsbergh VWM, Engelse MA, Quax PHA. Pericellular proteases in angiogenesis and vasculogenesis. 2006;26:716–728.
•Sata M. Role of circulating vascular progenitors in angiogenesis, vascular healing, and pulmonary hypertension: lessons from animal models. 2006;26:1008–1014.
•Liebner S, Cavallaro U, Dejana E. The multiple languages of endothelial cell-to-cell communication. 2006;26:1431–1438.

Angiogenesis, the process by which new blood vessels develop from a pre-existing vascular network, is essential for normal development and in certain physiological states. Inadequate or excessive angiogenesis has been incriminated in a number of pathologic states. For example, vaso-occlusive disease arising from atherosclerosis can lead to ischemia, a situation in which enhanced angiogenesis would be beneficial. Conversely, overzealous angiogenesis can contribute to tumor development and in this case inhibition of angiogenesis is desirable. Thus, strategies to induce or inhibit angiogenesis are of considerable therapeutic interest.

Angiogenesis is essential for normal development and homeostasis. Inadequate angiogenesis results in ischemia whereas overzealous angiogenesis can contribute to tumor development. In recent years, several transcription factors have been identified as directors of the angiogenic process. These factors and the mechanisms by whidch they exert their effects are reviewed.

Key Words: angiogenesis • endothelium • transcription • gene regulation

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