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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:1008.)
© 2006 American Heart Association, Inc.

Brief Reviews

Role of Circulating Vascular Progenitors in Angiogenesis, Vascular Healing, and Pulmonary Hypertension

Lessons From Animal Models

Masataka Sata

From the Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan; Department of Advanced Clinical Science and Therapeutics, University of Tokyo Graduate School of Medicine, Japan; and PRESTO, JST, Kawaguchi, Japan.

Reprint requests to Masataka Sata, MD, Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail msata-tky{at}umin.ac.jp

Series Editor: Stephanie Dimmeler
Novel Mediators and Mechanisms in Angiogenesis and Vasculogenesis
ATVB In Focus

Previous Brief Reviews in this Series:

•Ferguson JE III, Kelley RW, Patterson C. Mechanisms of endothelial differentiation in embryonic vasculogenesis. 2005;25:2245–2254.
•Werner N, Nickenig G. Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy? 2006;26:257–266.
•van Hinsbergh VWM, Engelse MA, Quax PHA. Pericellular proteases in angiogenesis and vasculogenesis. 2006;26:716–728.

Accumulating evidence suggests that circulating progenitors contribute to vascular healing and remodeling under physiological and pathological conditions. Although there is growing enthusiasm for therapeutic and diagnostic application of bone marrow–derived progenitors, there are concerns that transplanted precursors or bone marrow cells may participate in the pathogenesis of unfavorable diseases such as cancer, retinopathy, and atherosclerosis. This review summarizes recent findings obtained from animal models to examine the roles of circulating vascular progenitor cells in angiogenesis, pulmonary hypertension, and vascular healing.

Accumulating evidence suggests that bone marrow–derived circulating precursors contribute to vascular repair, remodeling, and lesion formation under physiological and pathological conditions. This article is intended to overview recent findings obtained from animal models of angiogenesis, pulmonary hypertension, and vascular healing.

Key Words: stem cell • angiogenesis • cancer • regeneration • progenitor

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