Published online before print February 9, 2006, doi: 10.1161/01.ATV.0000209501.56852.6c
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2006 American Heart Association, Inc.
Brief Reviews |
Dynamics and Plasticity of Weibel-Palade Bodies in Endothelial Cells
From the Department of Plasma Proteins (M.G.R., R.B., A.K., J.A.v.M., J.V.), Sanquin Research and Landsteiner Laboratory, AMC, University of Amsterdam, Amsterdam; Department of Vascular Medicine (J.A.v.M.), AMC, Amsterdam.
Correspondence to Jan Voorberg, Department of Plasma Proteins, Sanquin Research, Plesmanlaan 125, 1066 CX Amsterdam. E-mail j.voorberg{at}sanquin.nl
Agonist-induced release of endothelial cell specific storage granules, designated Weibel-Palade bodies (WPBs), provides the endothelium with the ability to rapidly respond to changes in its micro-environment. Originally being defined as an intracellular storage pool for von Willebrand factor (VWF), it has recently been shown that an increasing number of other components, including P-selectin, interleukin (IL)-8, eotaxin-3, endothelin-1, and angiopoietin-2, is present within this subcellular organelle, implicating a role for WPB exocytosis in inflammation, hemostasis, regulation of vascular tone and angiogenesis. Recent studies emphasize that WPBs provide a dynamic storage compartment whose contents can be regulated depending on the presence of inflammatory mediators in the vascular micro-environment. Additionally, release of WPBs is tightly regulated and feedback mechanisms have been identified that prevent excessive release of bioactive components from this subcellular organelle. The ability to regulate both contents and exocytosis of WPBs endows these endothelial cell specific organelles with a remarkable plasticity. This is most likely needed to allow for controlled delivery of bioactive components into the circulation on vascular perturbation.
Recent studies emphasize that Weibel-Palade bodies provide a dynamic storage compartment in endothelial cells whose contents can be regulated by inflammatory mediators present in the vascular micro-environment. This remarable plasticity of WPDs in most likely needed to allow for controlled delivery of bioactive comparats into the circulation upon vascular parturbation.
Key Words: endothelial cells • exocytosis • hemostasis • inflammation • Weibel-Palade body
This article has been cited by other articles:
 |
|
 |
|
  A. Reijerkerk, G. Kooij, S. M. A. van der Pol, T. Leyen, B. van het Hof, P.-O. Couraud, D. Vivien, C. D. Dijkstra, and H. E. de Vries Tissue-Type Plasminogen Activator Is a Regulator of Monocyte Diapedesis through the Brain Endothelial Barrier J. Immunol., September 1, 2008; 181(5): 3567 - 3574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Noubade, R. del Rio, B. McElvany, J. F. Zachary, J. M. Millward, D. D. Wagner, H. Offner, E. P. Blankenhorn, and C. Teuscher Von-Willebrand Factor Influences Blood Brain Barrier Permeability and Brain Inflammation in Experimental Allergic Encephalomyelitis Am. J. Pathol., September 1, 2008; 173(3): 892 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Melenovsky and G. Y.H. Lip Interleukin-8 and atrial fibrillation Europace, July 1, 2008; 10(7): 784 - 785. [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Rondaij, R. Bierings, E. L. van Agtmaal, K. A. Gijzen, E. Sellink, A. Kragt, S. S. G. Ferguson, K. Mertens, M. J. Hannah, J. A. van Mourik, et al. Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells Blood, July 1, 2008; 112(1): 56 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Voorberg Slipping out the Weibel-Palade body Blood, June 1, 2008; 111(11): 5264 - 5265. [Full Text] [PDF]
|
|
|
|
|
|
D. D. Wagner and P. S. Frenette The vessel wall and its interactions Blood, June 1, 2008; 111(11): 5271 - 5281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Babich, A. Meli, L. Knipe, J. E. Dempster, P. Skehel, M. J. Hannah, and T. Carter Selective release of molecules from Weibel-Palade bodies during a lingering kiss Blood, June 1, 2008; 111(11): 5282 - 5290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Metcalf, T. D. Nightingale, H. L. Zenner, W. W. Lui-Roberts, and D. F. Cutler Formation and function of Weibel-Palade bodies J. Cell Sci., January 1, 2008; 121(1): 19 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Rydkina, A. Sahni, D. J. Silverman, and S. K. Sahni Comparative analysis of host-cell signalling mechanisms activated in response to infection with Rickettsia conorii and Rickettsia typhi J. Med. Microbiol., July 1, 2007; 56(7): 896 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bezuidenhout, M. Bracher, G. Davison, P. Zilla, and N. Davies Ang-2 and PDGF-BB cooperatively stimulate human peripheral blood monocyte fibrinolysis J. Leukoc. Biol., June 1, 2007; 81(6): 1496 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Castanares, M. Redondo-Horcajo, N. Magan-Marchal, P. ten Dijke, S. Lamas, and F. Rodriguez-Pascual Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation J. Cell Sci., April 1, 2007; 120(7): 1256 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Into, Y. Kanno, J.-i. Dohkan, M. Nakashima, M. Inomata, K.-i. Shibata, C. J. Lowenstein, and K. Matsushita Pathogen Recognition by Toll-like Receptor 2 Activates Weibel-Palade Body Exocytosis in Human Aortic Endothelial Cells J. Biol. Chem., March 16, 2007; 282(11): 8134 - 8141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Simionescu Implications of Early Structural-Functional Changes in the Endothelium for Vascular Disease Arterioscler. Thromb. Vasc. Biol., February 1, 2007; 27(2): 266 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pfaff, U. Fiedler, and H. G. Augustin Emerging roles of the Angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking J. Leukoc. Biol., October 1, 2006; 80(4): 719 - 726. [Abstract] [Full Text] [PDF]
|
|