Published online before print January 5, 2006, doi: 10.1161/01.ATV.0000202677.55012.a0
© 2006 American Heart Association, Inc.
Vascular Biology |
Impact of Mouse Strain Differences in Innate Hindlimb Collateral Vasculature
From the Department of Experimental Cardiology (A.H., S.W., S.W., M.H., T.Z., U.B., W.S.), Max-Planck-Institute for Physiological & Clinical Research, Bad Nauheim, Germany; Angiogenesis Research Center & Section of Cardiology (A.H., M.D., U.B., J.D.P.), Dartmouth Medical School, Lebanon, NH; and EPR Center for Viable Biological Systems (N.K., H.M.S.), Dartmouth Medical School, Hanover, NH.
Correspondence to Armin Helisch, MD, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756. E-mail Armin.Helisch{at}dartmouth.edu
Objective— To assess the importance of genetic background for collateral artery development.
Methods and Results— C57BL/6, BALB/c and 129S2/Sv mice were studied after femoral artery ligation by laser Doppler imaging, visible light oximetry, time-of-flight–magnetic resonance imaging, and treadmill testing; C57BL/6 and BALB/c also underwent electron paramagnetic resonance (EPR) oximetry, x-ray angiography, and histology. C57BL/6 had the least initial distal ischemia and most complete recovery. BALB/c had the most severe initial ischemia and poorest recovery. BALB/c had some vasodilatory reserve in their ligated limbs not seen in the other strains at 3 weeks. By in vivo TOF-magnetic resonance angiography, C57BL/6 had larger preexistent and developed collaterals. By x-ray angiography, C57BL/6 had a higher collateral-dependent filling score and number of visible collaterals immediately after femoral ligation and a higher number of visible collaterals at 1 week but not at 4 weeks. EPR oximetry and histology revealed hypoxia and tissue damage in regions of collateral growth of BALB/c but not C57BL/6 mice. In C57BL/6 BrdUrd uptake in the thigh was limited to larger vessels and isolated perivascular cells. Proliferative activity in collateral arterioles was similar in both strains.
Conclusions— Genetic differences in preexistent collateral vasculature can profoundly affect outcome and milieu for compensatory collateral artery growth after femoral artery occlusion.
The purpose of this study was to assess the importance of genetic background for collateral artery development. Genetic differences in preexistent collateral vasculature can profoundly affect outcome and milieu for compensatory collateral artery growth after femoral artery occlusion.
Key Words: angiogenesis • collateral circulation • hypoxia • mouse strains • vascular biology
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