Published online before print May 19, 2005, doi: 10.1161/01.ATV.0000171155.05809.bf
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© 2005 American Heart Association, Inc.
Brief Reviews |
Signaling of the Tissue Factor Coagulation Pathway in Angiogenesis and Cancer
From the Department of Immunology, The Scripps Research Institute, La Jolla, Calif. Current address for Mattias Belting is Lund University, Department of Oncology, BMC C13, SE-222 84, Lund, Sweden.
Correspondence to Wolfram Ruf, MD, Department of Immunology, SP258, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037. E-mail ruf{at}scripps.edu
Activation of coagulation precedes or coincides with angiogenesis in wound healing and postischemic tissue regeneration. Advanced cancer is associated with a hypercoagulable state, and tissue factor expression by cancer cells has received widespread attention because of its significant contribution to the pathogenesis of cancer progression and metastasis. Our recent work demonstrates that tissue factor–mediated cellular signaling is relevant to cancer angiogenesis. Here we review the molecular mechanisms of tissue factor pathways in angiogenesis and tumorigenesis with emphasis on the intriguing role for tissue factor cytoplasmic domain signaling.
Activation of coagulation precedes or coincides with angiogenesis in wound healing and post-ischemic tissue regeneration. Advanced cancer is associated with a hypercoagulable state, and tissue factor expression by cancer cells has received widespread attention. Here we review the molecular mechanisms of tissue factor pathways in angiogenesis and tumorigenesis with emphasis on the intriguing role for tissue factor cytoplasmic domain signaling.
Key Words: protease activated receptors • metastasis • integrin
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