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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:1536.)
© 2005 American Heart Association, Inc.

Editorials

Lipoprotein Retention—and Clues for Atheroma Regression

Kevin Jon Williams; Ira Tabas

From the Dorrance H. Hamilton Research Laboratories, Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine (K.J.W.), Jefferson Medical College of Thomas Jefferson University, Philadelphia, Penn; and the Departments of Medicine, Anatomy & Cell Biology, and Physiology & Cellular Biophysics (I.T.), Columbia University, New York, NY.

Correspondence to Kevin Jon Williams, Department of Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 348, Philadelphia, PA 19107. E-mail K_Williams{at}mail.jci.tju.edu

Subendothelial retention of apoB-lipoproteins is the key initiating event in atherosclerosis, provoking a cascade of pathogenic responses. Dissection of the molecular participants provides fresh insight into how this major killer might be reversed. Efflux of harmful lipids derived from retained lipoproteins may be crucial in promoting beneficial remodeling of lesions.

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