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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:1135.)
© 2005 American Heart Association, Inc.

Brief Reviews

Vascular Implications of the Krüppel-Like Family of Transcription Factors

Toru Suzuki; Kenichi Aizawa; Takayoshi Matsumura; Ryozo Nagai

From the Departments of Cardiovascular Medicine (T.S., K.A., T.M., R.N.) and Clinical Bioinformatics (T.S.), Graduate School of Medicine, The University of Tokyo, Japan.

Correspondence to Toru Suzuki, MD, PhD, Department of Cardiovascular Medicine, Department of Clinical Bioinformatics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail torusuzu-tky{at}umin.ac.jp

The Krüppel-like factor (KLF) family is a recently highlighted group of zinc finger transcription factors given their important biological roles which include the vasculature. KLF2, KLF4, KLF5, and KLF6 are notable factors that have been implicated in developmental as well as pathological vascular processes. In this brief review, we provide an up-to-date summary of the physiological functions and cellular effects as well as transcriptional regulatory mechanisms of the vascular KLFs. Through such, we aim to provide a working view for understanding the pathological actions of KLFs in the vasculature.

The Krüppel-like factor (KLF) family is a recently highlighted group of zinc finger transcription factors given their important biological roles, which include the vasculature. KLF2, KLF4, KLF5, and KLF6 are notable factors that have been implicated in developmental as well as pathological vascular processes. In this brief review, we aim to provide a working view for understanding the pathological actions of KLFs in the vasculature.

Key Words: transcription • gene expression • zinc finger • Krüppel-like factor

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