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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:1038.)
© 2005 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Association Between Serum Uric Acid, Metabolic Syndrome, and Carotid Atherosclerosis in Japanese Individuals

Nobukazu Ishizaka; Yuko Ishizaka; Ei-Ichi Toda; Ryozo Nagai; Minoru Yamakado

From the Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine (N.I., R.N.), and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital (Y.I., E-I.T., M.Y.), Tokyo, Japan.

Correspondence to Dr Nobukazu Ishizaka, Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7-3-1 Bunkyo-ku, Tokyo 113-8655, Japan. E-mail nobuishizka-tky{at}umin.ac.jp

Objective— There are few data available on possible independent association between uric acid and carotid atherosclerosis. Here we first sought to investigate association between uric acid levels and metabolic syndrome in Japanese; second, we assessed whether there is an independent association of uric acid with prevalence of carotid atherosclerosis in individuals subdivided according to gender and metabolic syndrome status.

Methods and Results— Cross-sectional data from 8144 individuals who underwent general health screening were analyzed. After adjusting for age, total cholesterol, and smoking status, the odds ratios (95% CI) of sex-specific quartiles of serum uric acid for metabolic syndrome were 1.0, 1.06 (0.60 to 1.87), 2.18 (1.30 to 3.64), and 4.17 (2.56 to 6.79) in women, and 1.0, 0.92 (0.74 to 1.14), 1.52 (1.25 to 1.65), and 1.97 (1.61 to 2.40) in men. After adjusting for age, serum levels, total cholesterol, and smoking status, prevalence of carotid plaque was higher in subjects in the second, third, and fourth quartiles of uric acid level with odds ratios (95% CI) of 1.24 (1.01 to 1.52), 1.37 (1.11 to 1.68), and 1.31 (1.05 to 1.63), respectively, in men without metabolic syndrome but not in men with metabolic syndrome or in women with or without metabolic syndrome.

Conclusion— The prevalence of metabolic syndrome showed a graded increase according to serum uric acid values in both genders. In men who did not have metabolic syndrome, uric acid was found to be an independent risk factor for incidence of carotid plaque.

Whether there is an independent association of uric acid with prevalence of carotid atherosclerosis was analyzed. Serum uric acid values are associated with carotid plaque independently of other atherogenic risk factors in men without but not with metabolic syndrome or in women at all.

Key Words: metabolic syndrome • carotid atherosclerosis • ultrasonography • insulin resistance • multivariate analysis

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