Published online before print February 3, 2005, doi: 10.1161/01.ATV.0000157982.69663.59
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2005 American Heart Association, Inc.
Atherosclerosis & Lipoproteins |
Serum Antibody Levels to Actinobacillus actinomycetemcomitans Predict the Risk for Coronary Heart Disease
From the Institute of Dentistry (P.J.P.), University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki; the Research Institute of Public Health (K.N., R.S., J.A.L., J.T.S.), University of Kuopio; the Department of Health and Functional Ability (G.A.), National Public Health Institute, Helsinki; Savonlinna Central Hospital (J.A.L.), Savonlinna; and Oy Jurilab Ltd (J.T.S.), Kuopio, Finland.
Correspondence to Pirkko Pussinen, Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, P.O. Box 63, FI-00014 Helsinki, Finland. E-mail pirkko.pussinen{at}helsinki.fi
Objective— The association between serum antibody levels to major periodontal pathogens and coronary heart disease (CHD) was analyzed in a prospective population-based study.
Methods and Results— The population comprised 1023 men (aged 46 to 64 years) in the Kuopio Ischemic Heart Disease Study. The subjects with CHD at baseline (n=113) were more often seropositive for Porphyromonas gingivalis IgA (38.9% versus 28.5%, P=0.021) and IgG (60.2% versus 46.7%, P=0.007) than those without CHD. During the 10-year follow-up, 109 men free from CHD at baseline experienced an acute myocardial infarction or CHD death. The men with an end point were more often seropositive for Actinobacillus actinomycetemcomitans IgA (15.5% versus 10.2%, P=0.019) than those who remained healthy. In the highest tertile of A. actinomycetemcomitans IgA-antibodies compared with the lowest one, the relative risk (RR) for an end point adjusted for CHD risk factors was 2.0 (95% confidence interval [CI], 1.2 to 3.3). In the Porphyromonas gingivalis IgA-antibody tertiles, the highest RR of 2.1 (1.3 to 3.4) was observed in the second tertile. All antibody levels correlated positively with the carotid artery intima-media thickness.
Conclusions— High-serum antibody levels to major periodontal pathogens are associated with subclinical, prevalent, and future incidence of CHD. Periodontal pathogens or host response against them may contribute to the pathogenesis of CHD.
The association between serum antibody levels to periodontal pathogens and coronary heart disease (CHD) was analyzed in a prospective population-based study comprising 1023 men in the Kuopio Ischemic Heart Disease Study. High-serum antibody levels to major periodontal pathogens were associated with subclinical, prevalent, and future incidence of CHD.
Key Words: atherosclerosis • cardiovascular diseases • infection • inflammation • periodontitis
This article has been cited by other articles:
 |
|
 |
|
  S. I. van Leuven, R. Hezemans, J. H. Levels, S. Snoek, P. C. Stokkers, G. K. Hovingh, J. J. P. Kastelein, E. S. Stroes, E. de Groot, and D. W. Hommes Enhanced atherogenesis and altered high density lipoprotein in patients with Crohn's disease J. Lipid Res., December 1, 2007; 48(12): 2640 - 2646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Tuomainen, K. Nyyssonen, J. A. Laukkanen, T. Tervahartiala, T.-P. Tuomainen, J. T. Salonen, T. Sorsa, and P. J. Pussinen Serum Matrix Metalloproteinase-8 Concentrations Are Associated With Cardiovascular Outcome in Men Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2722 - 2728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Tang, T. Ruiz, R. Barrantes-Reynolds, and K. P. Mintz Molecular heterogeneity of EmaA, an oligomeric autotransporter adhesin of Aggregatibacter (Actinobacillus) actinomycetemcomitans Microbiology, August 1, 2007; 153(8): 2447 - 2457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Pussinen, K. Tuomisto, P. Jousilahti, A. S. Havulinna, J. Sundvall, and V. Salomaa Endotoxemia, Immune Response to Periodontal Pathogens, and Systemic Inflammation Associate With Incident Cardiovascular Disease Events Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): 1433 - 1439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Vilkuna-Rautiainen, P. J Pussinen, M. Roivainen, T. Petays, P. Jousilahti, T. Hovi, E. Vartiainen, and S. Asikainen Serum antibody response to periodontal pathogens and herpes simplex virus in relation to classic risk factors of cardiovascular disease Int. J. Epidemiol., December 1, 2006; 35(6): 1486 - 1494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Demmer and M. Desvarieux Periodontal infections and cardiovascular disease: The heart of the matter J Am Dent Assoc, October 1, 2006; 137(suppl_2): 14S - 20S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Fernandez-Real, A. Lopez-Bermejo, J. Vendrell, M.-J. Ferri, M. Recasens, and W. Ricart Burden of Infection and Insulin Resistance in Healthy Middle-Aged Men Diabetes Care, May 1, 2006; 29(5): 1058 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-T.A. Teng Protective and Destructive Immunity in the Periodontium: Part 2--T-cell-mediated Immunity in the Periodontium. J. Dent. Res., March 1, 2006; 85(3): 209 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lakio, M. Lehto, A. M. Tuomainen, M. Jauhiainen, E. Malle, S. Asikainen, and P. J. Pussinen Pro-atherogenic properties of lipopolysaccharide from the periodontal pathogen Actinobacillus actinomycetemcomitans Innate Immunity, February 1, 2006; 12(1): 57 - 64. [Abstract] [PDF]
|
|