Published online before print October 28, 2004, doi: 10.1161/01.ATV.0000149143.04821.eb
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© 2005 American Heart Association, Inc.
Brief Reviews |
Redox Mechanisms in Blood Vessels
From Emory University Division of Cardiology, Department of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, Ga.
Correspondence to David G. Harrison, Division of Cardiology, Emory University, 1639 Pierce Drive, WMRB 319, Atlanta, GA 30322. E-mail dharr02{at}emory.edu
Series Editor: Kathy K. Griendling
Reactive oxygen species have been implicated in the pathogenesis of virtually every stage of vascular lesion formation, hypertension, and other vascular diseases. We are currently gaining insight into important sources of reactive oxygen species in the vessel wall, including the NADPH oxidases, xanthine oxidase, uncoupled nitric oxide synthase, and mitochondrial sources. Although various reactive oxygen species have pathological roles, some serve as important signaling molecules that modulate vascular tone, growth, and remodeling. In the next several months, a series of articles in Arteriosclerosis, Thrombosis, and Vascular Biology attempt to further elucidate how reactive oxygen species are produced by vascular cells and the roles of these in vascular homeostasis. This series promises to provide a valuable update on a wide variety of issues related to the biochemistry, molecular biology, and physiology of these important and fascinating molecules.
Reactive oxygen species have been implicated in the pathogenesis of virtually every stage of vascular lesion formation, hypertension, and other vascular diseases. Upcoming series of articles in Arteriosclerosis, Thrombosis, and Vascular Biology help elucidate how reactive oxygen species are produced by vascular cells and their role in vascular homeostasis.
Key Words: NADPH oxidase • superoxide • nitric oxide synthase • xanthine oxidase • mitochondria
Related Article:
Arterioscler. Thromb. Vasc. Biol. 2005 25: 272-273.
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