This Article Full Text Full Text (PDF) All Versions of this Article: 24/9/1558    most recent 01.ATV.0000136649.83297.bfv1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Scott, E. M. Articles by Grant, P. J. Search for Related Content PubMed PubMed Citation Articles by Scott, E. M. Articles by Grant, P. J. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Compound via MeSH Substance via MeSH Related Collections Pathophysiology Coagulation Fibrinogen/fibrin

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:1558.)
© 2004 American Heart Association, Inc.

Brief Reviews

Genetic and Environmental Determinants of Fibrin Structure and Function

Relevance to Clinical Disease

Eleanor M. Scott; Robert A.S. Ariëns; Peter J. Grant

From the Academic Unit of Molecular Vascular Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.

Correspondence to Prof P.J. Grant, Academic Unit of Molecular Vascular Medicine, Martin Wing, The General Infirmary at Leeds, Leeds, LS1 3EX, UK. E-mail P.J.Grant{at}Leeds.ac.uk

The formation of a fibrin clot is one of the key events in atherothrombotic vascular disease. The structure of the fibrin clot and the genetic and environmental factors that modify it have effects on its biological function. Alterations in fibrin structure and function have implications for the clinical presentation of vascular disease. This review briefly describes the key features involved in the formation of a fibrin clot, its typical structure, and function. This is followed by a review of the current literature on genetic and environmental influences on fibrin structure/function and the relationship to clinical disease.

The formation of a fibrin clot is one of the key events in atherothrombotic vascular disease. This review discusses how genetic and environmental factors alter fibrin structure and function and the implications this has for the clinical presentation of vascular disease.

Key Words: fibrin • hemostatis • genetic • environment • atherothrombosis

This article has been cited by other articles:

				A. Undas, P. Podolec, K. Zawilska, M. Pieculewicz, I. Jedlinski, E. Stepien, E. Konarska-Kuszewska, P. Weglarz, M. Duszynska, E. Hanschke, et al. Altered Fibrin Clot Structure/Function in Patients With Cryptogenic Ischemic Stroke Stroke, April 1, 2009; 40(4): 1499 - 1501. [Abstract] [Full Text] [PDF]

				A. Undas, I. Wiek, E. Stepien, K. Zmudka, and W. Tracz Hyperglycemia Is Associated With Enhanced Thrombin Formation, Platelet Activation, and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary Syndrome Diabetes Care, August 1, 2008; 31(8): 1590 - 1595. [Abstract] [Full Text] [PDF]

				A. Undas, M. Kolarz, G. Kopec, and W. Tracz Altered fibrin clot properties in patients on long-term haemodialysis: relation to cardiovascular mortality Nephrol. Dial. Transplant., June 1, 2008; 23(6): 2010 - 2015. [Abstract] [Full Text] [PDF]

				J. Suntharalingam, K. Goldsmith, V. van Marion, L. Long, C. M. Treacy, F. Dudbridge, M. R. Toshner, J. Pepke-Zaba, J. C. J. Eikenboom, and N. W. Morrell Fibrinogen A{alpha} Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension Eur. Respir. J., April 1, 2008; 31(4): 736 - 741. [Abstract] [Full Text] [PDF]

				D. M. O. Pruissen, A. J. C. Slooter, F. R. Rosendaal, Y. van der Graaf, and A. Algra Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke Blood, February 1, 2008; 111(3): 1282 - 1286. [Abstract] [Full Text] [PDF]

				J. R. Cerhan, S. M. Ansell, Z. S. Fredericksen, N. E. Kay, M. Liebow, T. G. Call, A. Dogan, J. M. Cunningham, A. H. Wang, W. Liu-Mares, et al. Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma Blood, December 15, 2007; 110(13): 4455 - 4463. [Abstract] [Full Text] [PDF]

				J. Zalewski, A. Undas, J. Godlewski, E. Stepien, and K. Zmudka No-Reflow Phenomenon After Acute Myocardial Infarction Is Associated With Reduced Clot Permeability and Susceptibility to Lysis Arterioscler. Thromb. Vasc. Biol., October 1, 2007; 27(10): 2258 - 2265. [Abstract] [Full Text] [PDF]

				A. Silveira and A. Hamsten Fibrin gel architecture influences endogenous fibrinolysis and may promote coronary artery disease. Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2419 - 2420. [Full Text] [PDF]

				J.P. Collet, Y. Allali, C. Lesty, M.L. Tanguy, J. Silvain, A. Ankri, B. Blanchet, R. Dumaine, J. Gianetti, L. Payot, et al. Altered Fibrin Architecture Is Associated With Hypofibrinolysis and Premature Coronary Atherothrombosis Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2567 - 2573. [Abstract] [Full Text] [PDF]

				A. Undas, J. Brozek, M. Jankowski, Z. Siudak, A. Szczeklik, and H. Jakubowski Plasma Homocysteine Affects Fibrin Clot Permeability and Resistance to Lysis in Human Subjects Arterioscler. Thromb. Vasc. Biol., June 1, 2006; 26(6): 1397 - 1404. [Abstract] [Full Text] [PDF]