Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:1015-1022
Published online before print April 29, 2004, doi: 10.1161/01.ATV.0000130465.23430.74
Published online before print April 29, 2004, doi: 10.1161/01.ATV.0000130465.23430.74
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2004 American Heart Association, Inc.
Brief Reviews |
Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development
From The Scripps Research Institute, Departments of Immunology & Cell Biology, La Jolla, Calif.
Correspondence to Dr Nigel Mackman, The Scripps Research Institute, Departments of Immunology & Cell Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037. E-mail nmackman{at}scripps.edu
Tissue factor (TF) is best known as the primary cellular initiator of blood coagulation. After vessel injury, the TF:FVIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets. TF deficiency causes embryonic lethality in the mouse and there have been no reports of TF deficiency in humans. These results indicate that TF is essential for life, most likely because of its central role in hemostasis. In addition, aberrant TF expression within the vasculature initiates life-threatening thrombosis in various diseases, such as sepsis, atherosclerosis, and cancer. Finally, recent studies have revealed a nonhemostatic role of TF in the generation of coagulation proteases and subsequent activation of protease activated receptors (PARs) on vascular cells. This TF-dependent signaling contributes to a variety of biological processes, including inflammation, angiogenesis, metastasis, and cell migration. This review focuses on the roles of TF in hemostasis, thrombosis, and vascular development.
Tissue factor (TF) expression by nonvascular cells plays an essential role in hemostasis by activating blood coagulation. In contrast, TF expression by vascular cells induces intravascular thrombosis. Finally, TF-dependent assembly of coagulation proteases on vascular cells activates protease activated receptors, which contributes to inflammation, angiogenesis, and metastasis.
Key Words: tissue factor • coagulation proteases • PAR signaling
This article has been cited by other articles:
 |
|
 |
|
  G. KRIKUN, F. SCHATZ, H. TAYLOR, and C. J. LOCKWOOD Endometriosis and Tissue Factor Ann. N.Y. Acad. Sci., April 1, 2008; 1127(1): 101 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Mackman and M. B. Taubman Does Tissue Factor Expression by Vascular Smooth Muscle Cells Provide a Link Between C-Reactive Protein and Cardiovascular Disease? Arterioscler. Thromb. Vasc. Biol., April 1, 2008; 28(4): 601 - 603. [Full Text] [PDF]
|
|
|
|
|
|
S.K. Payeli, R. Latini, C. Gebhard, A. Patrignani, U. Wagner, T.F. Luscher, and F.C. Tanner Prothrombotic Gene Expression Profile in Vascular Smooth Muscle Cells of Human Saphenous Vein, but Not Internal Mammary Artery Arterioscler. Thromb. Vasc. Biol., April 1, 2008; 28(4): 705 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Szlam, T. Taketomi, C. A. Sheppard, C. L. Kempton, J. H. Levy, and K. A. Tanaka Antithrombin Affects Hemostatic Response to Recombinant Activated Factor VII in Factor VIII Deficient Plasma Anesth. Analg., March 1, 2008; 106(3): 719 - 724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T.B. Crawley and D. A. Lane The Haemostatic Role of Tissue Factor Pathway Inhibitor Arterioscler. Thromb. Vasc. Biol., February 1, 2008; 28(2): 233 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gailani and T. Renne Intrinsic Pathway of Coagulation and Arterial Thrombosis Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2507 - 2513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Boden, V. R. Vaidyula, C. Homko, P. Cheung, and A. K. Rao Circulating Tissue Factor Procoagulant Activity and Thrombin Generation in Patients with Type 2 Diabetes: Effects of Insulin and Glucose J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4352 - 4358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wang, S. A. Mahmud, P. B. Bitterman, Y. Huo, and A. Slungaard Histone Deacetylase Inhibitors Suppress TF-{kappa}B-dependent Agonist-driven Tissue Factor Expression in Endothelial Cells and Monocytes J. Biol. Chem., September 28, 2007; 282(39): 28408 - 28418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ghosh, H. Wang, Y. Ai, E. Romeo, J. P. Luyendyk, J. M. Peters, N. Mackman, S. K. Dey, and T. Hla COX-2 suppresses tissue factor expression via endocannabinoid-directed PPAR{delta} activation J. Exp. Med., September 3, 2007; 204(9): 2053 - 2061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. White, D. F. Meoli, R. F. Swarthout, D. Y. Kallop, I. I. Galaria, J. L. Harvey, C. M. Miller, B. C. Blaxall, C. M. Hall, R. A. Pierce, et al. Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L583 - L590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Versteeg and W. Ruf Tissue Factor Coagulant Function Is Enhanced by Protein-disulfide Isomerase Independent of Oxidoreductase Activity J. Biol. Chem., August 31, 2007; 282(35): 25416 - 25424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Panes, V. Matus, C. G. Saez, T. Quiroga, J. Pereira, and D. Mezzano Human platelets synthesize and express functional tissue factor Blood, June 15, 2007; 109(12): 5242 - 5250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Boden, V. Vaidyula, C. Homko, M. Mozzoli, and A. K. Rao Differential effects of somatostatin on circulating tissue factor procoagulant activity and protein Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1333 - E1339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Cai, C. Song, I. Endoh, J. Goyette, W. Jessup, S. B. Freedman, H. P. McNeil, and C. L. Geczy Serum Amyloid A Induces Monocyte Tissue Factor J. Immunol., February 1, 2007; 178(3): 1852 - 1860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-G. Wang, S. A. Mahmud, J. Nguyen, and A. Slungaard Thiocyanate-Dependent Induction of Endothelial Cell Adhesion Molecule Expression by Phagocyte Peroxidases: A Novel HOSCN-Specific Oxidant Mechanism to Amplify Inflammation J. Immunol., December 15, 2006; 177(12): 8714 - 8722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Schwertz, N. D. Tolley, J. M. Foulks, M. M. Denis, B. W. Risenmay, M. Buerke, R. E. Tilley, M. T. Rondina, E. M. Harris, L. W. Kraiss, et al. Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenecity of human platelets J. Exp. Med., October 30, 2006; 203(11): 2433 - 2440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Camici, J. Steffel, A. Akhmedov, N. Schafer, J. Baldinger, U. Schulz, K. Shojaati, C. M. Matter, Z. Yang, T. F. Luscher, et al. Dimethyl Sulfoxide Inhibits Tissue Factor Expression, Thrombus Formation, and Vascular Smooth Muscle Cell Activation: A Potential Treatment Strategy for Drug-Eluting Stents Circulation, October 3, 2006; 114(14): 1512 - 1521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ahamed, H. H. Versteeg, M. Kerver, V. M. Chen, B. M. Mueller, P. J. Hogg, and W. Ruf Disulfide isomerization switches tissue factor from coagulation to cell signaling PNAS, September 19, 2006; 103(38): 13932 - 13937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shoji, H. Koyama, T. Morioka, S. Tanaka, A. Kizu, K. Motoyama, K. Mori, S. Fukumoto, A. Shioi, N. Shimogaito, et al. Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes. Diabetes, August 1, 2006; 55(8): 2245 - 2255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Stahli, G. G. Camici, J. Steffel, A. Akhmedov, K. Shojaati, M. Graber, T. F. Luscher, and F. C. Tanner Paclitaxel Enhances Thrombin-Induced Endothelial Tissue Factor Expression via c-Jun Terminal NH2 Kinase Activation Circ. Res., July 21, 2006; 99(2): 149 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Stoll and M. Bendszus Inflammation and Atherosclerosis: Novel Insights Into Plaque Formation and Destabilization Stroke, July 1, 2006; 37(7): 1923 - 1932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Uzonyi, K. Lotzer, S. Jahn, C. Kramer, M. Hildner, E. Bretschneider, D. Radke, M. Beer, R. Vollandt, J. F. Evans, et al. Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells PNAS, April 18, 2006; 103(16): 6326 - 6331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Athanasopoulos, M. Economopoulou, V. V. Orlova, A. Sobke, D. Schneider, H. Weber, H. G. Augustin, S. A. Eming, U. Schubert, T. Linn, et al. The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms Blood, April 1, 2006; 107(7): 2720 - 2727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kleinschnitz, G. Stoll, M. Bendszus, K. Schuh, H.-U. Pauer, P. Burfeind, C. Renne, D. Gailani, B. Nieswandt, and T. Renne Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis J. Exp. Med., March 20, 2006; 203(3): 513 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Colman Are hemostasis and thrombosis two sides of the same coin? J. Exp. Med., March 20, 2006; 203(3): 493 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Tilley, B. Pedersen, R. Pawlinski, Y. Sato, J. H. Erlich, Y. Shen, S. Day, Y. Huang, D. T. Eitzman, W. A. Boisvert, et al. Atherosclerosis in Mice Is Not Affected by a Reduction in Tissue Factor Expression Arterioscler. Thromb. Vasc. Biol., March 1, 2006; 26(3): 555 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-G. Wang, S. A. Mahmud, J. A. Thompson, J.-G. Geng, N. S. Key, and A. Slungaard The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states Blood, January 15, 2006; 107(2): 558 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. R. Vaidyula, A. K. Rao, M. Mozzoli, C. Homko, P. Cheung, and G. Boden Effects of Hyperglycemia and Hyperinsulinemia on Circulating Tissue Factor Procoagulant Activity and Platelet CD40 Ligand Diabetes, January 1, 2006; 55(1): 202 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Parolari, L. Mussoni, M. Frigerio, M. Naliato, F. Alamanni, G. L. Polvani, M. Agrifoglio, F. Veglia, E. Tremoli, P. Biglioli, et al. The role of tissue factor and P-selectin in the procoagulant response that occurs in the first month after on-pump and off-pump coronary artery bypass grafting J. Thorac. Cardiovasc. Surg., December 1, 2005; 130(6): 1561 - 1566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mackman Tissue-Specific Hemostasis in Mice Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2273 - 2281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Renne, M. Pozgajova, S. Gruner, K. Schuh, H.-U. Pauer, P. Burfeind, D. Gailani, and B. Nieswandt Defective thrombus formation in mice lacking coagulation factor XII J. Exp. Med., July 18, 2005; 202(2): 271 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pedersen, T. Holscher, Y. Sato, R. Pawlinski, and N. Mackman A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice Blood, April 1, 2005; 105(7): 2777 - 2782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Hugel, M. C. Martinez, C. Kunzelmann, and J.-M. Freyssinet Membrane Microparticles: Two Sides of the Coin Physiology, February 1, 2005; 20(1): 22 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. V. M. Rao and U. R. Pendurthi Tissue Factor-Factor VIIa Signaling Arterioscler. Thromb. Vasc. Biol., January 1, 2005; 25(1): 47 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Day, J. L. Reeve, B. Pedersen, D. M Farris, D. D. Myers, M. Im, T. W. Wakefield, N. Mackman, and W. P. Fay Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall Blood, January 1, 2005; 105(1): 192 - 198. [Abstract] [Full Text] [PDF]
|
|