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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:1970.)
© 2004 American Heart Association, Inc.

Thrombosis

Serum Lipid Levels and the Risk of Venous Thrombosis

Carine J.M. Doggen; Nicholas L. Smith; Rozenn N. Lemaitre; Susan R. Heckbert; Frits R. Rosendaal; Bruce M. Psaty

From the Departments of Epidemiology (C.J.M.D., N.L.S., S.R.H., F.R.R., B.M.P.), Medicine (R.N.L., B.M.P.), and Health Services (B.M.P.), University of Washington, Seattle; and the Departments of Clinical Epidemiology (C.J.M.D., F.R.R.) and Hematology (F.R.R.), Leiden University Medical Center, Leiden, the Netherlands.

Correspondence to Carine J.M. Doggen, Clinical Epidemiology, Albinusdreef 2, Leiden University Medical Center C9-P, PO Box 9600, 2300 RC Leiden, the Netherlands. E-mail C.J.M.Doggen{at}lumc.nl

Objective— Lipids, through effects on the coagulation and fibrinolytic systems, may contribute to the development of venous thrombosis. This association has been investigated in a few studies, with conflicting results.

Methods and Results— We conducted a population-based, case-control study at a health maintenance organization in Washington State, to assess the association of serum lipid levels with the risk of venous thrombosis. Cases were 477 postmenopausal women with a first venous thrombosis during January 1995 through December 2001. Control subjects (1986) were a random sample of postmenopausal women. Medical records, computerized pharmacy databases, and a cancer registry served to collect data on lipid levels and risk factors for thrombosis. Total cholesterol levels were not associated with venous thrombosis. Only high HDL cholesterol levels were associated with a decreased risk of venous thrombosis after adjustment for hospitalization, malignancy, height and weight, postmenopausal hormone therapy, and vascular disease (for high-density lipoprotein [HDL] cholesterol levels >1.79 mmol/L versus those <1.79 mmol/L; odds ratio [OR], 0.71; 95% confidence interval [CI], 0.52 to 0.97). In contrast, elevated triglyceride levels were associated with an increased risk (OR, 2.13; 95% CI, 1.34 to 3.37) for women with triglyceride levels >1.05 mmol/L compared with women with lower levels.

Conclusion— Elevated triglyceride levels were associated with a doubling of risk of venous thrombosis in postmenopausal women, whereas elevated HDL cholesterol levels were associated with a decreased risk.

In a population-based case-control study including 477 postmenopausal women with a first venous thrombosis and 1986 control subjects, elevated triglyceride levels were associated with a 2-fold increased risk of venous thrombosis, whereas high HDL cholesterol was associated with a decreased risk. Total cholesterol levels were not associated with venous thrombosis.

Key Words: total cholesterol • high-density lipoprotein cholesterol • triglycerides • venous thrombosis • risk

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