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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:1874.)
© 2004 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

C-Reactive Protein Genotypes Affect Baseline, but not Exercise Training–Induced Changes, in C-Reactive Protein Levels

Thomas O. Obisesan; Christiaan Leeuwenburgh; Tracey Phillips; Robert E. Ferrell; Dana A. Phares; Steven J. Prior; James M. Hagberg

From the Department of Kinesiology (T.O.O., D.A.P., S.J.P., J.M.H.), University of Maryland, College Park, Md; the Section of Geriatrics (T.O.O.), Department of Medicine, Howard University Hospital, Washington DC; Biochemistry of Aging Laboratory (C.L., T.P.), College of Medicine and Health and Human Performance, University of Florida, Gainesville, Fla; and the Department of Human Genetics (R.E.F.), University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pa.

Correspondence to Dr James Hagberg, Department of Kinesiology, University of Maryland, College Park, MD 20742-2611. E-mail hagberg{at}umd.edu

Objective— The goal of this study is to determine whether C-reactive protein (CRP) gene variants affect baseline and training-induced changes in plasma CRP levels.

Methods and Results— Sixty-three sedentary men and women aged 50 to 75 years old underwent baseline testing (VOmax, body composition, CRP levels). They repeated these tests after 24 weeks of exercise training while on a low-fat diet. The CRP +219G/A variant significantly associated with CRP levels before and after training after accounting for the effects of demographic and biological variables. CRP –732A/G genotype was significantly related on a univariate basis to CRP levels after training. The CRP +29T/A variant did not affect CRP levels before or after training. In regression analyses, the +219 and –732 variants each had significant effects on CRP levels before and after training. Subjects homozygous for the common A/G –732/+219 haplotype exhibited the highest CRP levels, and having the rare allele at either site was associated with significantly lower CRP levels. CRP levels decreased significantly with training (–0.38±0.18 mg/L; P=0.03). However, none of the CRP variants was associated with the training-induced CRP changes.

Conclusion— CRP +219G/A and –732A/G genotypes and haplotypes and exercise training appear to modulate CRP levels. However, training-induced CRP reductions appear to be independent of genotype at these loci.

We determined whether CRP gene variants affect baseline CRP levels and whether these variants interact with exercise training to affect CRP levels. CRP +219G/A and –732A/G genotypes and exercise training appear to modulate CRP levels. However, the training-induced CRP reductions appear to be independent of genotype at these loci.

Key Words: C-reactive protein • genetics • exercise training

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