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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:1868.)
© 2004 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Can Exercise Training With Weight Loss Lower Serum C-Reactive Protein Levels?

Koichi Okita; Hirotaka Nishijima; Takeshi Murakami; Tatsuya Nagai; Noriteru Morita; Kazuya Yonezawa; Kenji Iizuka; Hideaki Kawaguchi; Akira Kitabatake

From the Departments of Cardiovascular Medicine and Laboratory Medicine, Hokkaido University Graduate School of Medicine, and Sapporo Health Promotion Center, Sapporo, Japan.

Correspondence to Koichi Okita MD, PhD, Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan. E-mail okita{at}med.hokudai.ac.jp

Objective— C-reactive protein (CRP), an obesity-related inflammatory marker, is a promising predictor for cardiovascular disease and may be a mediator for atherogenesis. It has been reported that diet-induced weight loss lowered CRP levels. However, the effect of exercise training, another therapy that can reduce weight, on CRP is still unclear. We examined effects of exercise training with weight loss on CRP levels and conventional cardiovascular risks.

Methods and Results— A total of 227 apparently healthy women were recruited, and 199 subjects (average age 52 years) completed a 2-month weight reduction program consisting of supervised aerobic exercises. After the program, weight was reduced from 65.8 to 62.8 kg (P<0.0001), and all conventional variables were remarkably improved. Similarly, CRP levels were significantly decreased, from 0.63 (0.28 to 1.19) to 0.41 (0.18 to 0.80) mg/L (P<0.0001). However, in contrast to other variables, the changes in CRP levels were not proportionally associated with the extent of weight reduction. In the quartile analysis of % weight reduction, the largest weight reduction quartile did not show significant decreases in CRP levels, whereas moderate quartile showed remarkable CRP decreases.

Conclusions— Exercise training with weight reduction disproportionately lowered CRP levels. Considering inflammatory status, there might be an optimal pace of exercise with weight loss.

C-reactive protein (CRP) is a promising predictor for cardiovascular disease and may be a mediator for atherogenesis. Although it has been reported that diet-induced weight loss lowered CRP levels, the effect of exercise training on CRP is still unclear. We examined effects of exercise training with weight loss on CRP levels, finding that exercise training with weight reduction disproportionately lowered CRP levels. Considering inflammatory status, there might be an optimal pace of exercise with weight loss.

Key Words: C-reactive protein • atherosclerosis • inflammation • obesity • risk factors • exercise

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