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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:1501.)
© 2003 American Heart Association, Inc.

Brief Reviews

Using Mice to Dissect Genetic Factors in Atherosclerosis

Hooman Allayee; Anatole Ghazalpour; Aldons J. Lusis

From the Departments of Human Genetics (H.A., A.J.L.); Microbiology, Immunology, and Molecular Genetics (A.G., A.J.L.); and Medicine (A.J.L.), and the Molecular Biology Institute (A.J.L.), David Geffen School of Medicine at UCLA, Los Angeles, Calif.

Reprint requests to Aldons J. Lusis, PhD, Department of Medicine, Division of Cardiology, 47-123 Center for the Health Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095. E-mail jlusis{at}mednet.ucla.edu

Series Editor: James Scott
ATVB in Focus

Lipoproteins, Inflammation, and Atherosclerosis

Previous Brief Reviews in this Series:

•Pennachhio LA, Rubin EM. Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice. 2003;23:529–534.
•Cullen P, Baetta R, Bellosta S, Bernini F, Chinetti G, Cignarella A, von Eckardstein A, Exley A, Goddard M, Hofker M, Hurt-Camejo E, Kanters E, Kovanen P, Lorkowski S, McPheat W, Pentikäinen M, Rauterberg J, Ritchie A, Staels B, Weitkamp B, de Winther M for the MAFAPS Consortium. Rupture of the atherosclerotic plaque: does a good animal model exist? 2003;23:535–542.

The genes that contribute to common, complex forms of atherosclerosis remain largely unknown. Genetic studies in humans have, for the most part, focused on identifying genes that predispose to the traditional risk factors, such as lipid levels and blood pressure, but apart from rare, single-gene disorders, there have been few successes to date. The use of mice to dissect the complex genetic etiology of atherosclerosis offers a viable alternative to human studies, because experimental parameters, such as environment, breeding scheme, and detailed phenotyping, can be controlled. Herein we review how mouse genetics can lead to the identification of genes, some of which would otherwise not have been considered as candidates for atherosclerosis, and provide an overview of the prospects for successful gene discovery in the future.

Key Words: atherosclerosis • genetic factors

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