Published online before print June 12, 2003, doi: 10.1161/01.ATV.0000079007.40884.5C
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2003 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Angiotensinogen Gene Polymorphism, Plasma Angiotensinogen, and Risk of Hypertension and Ischemic Heart Disease
A Meta-Analysis
From the Department Clinical Biochemistry (A.A.S., B.G.N.), Herlev University Hospital and Department Clinical Biochemistry (A.T.H.), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Correspondence to Anne Tybjærg-Hansen, MD, DMSc, Department of Clinical Biochemistry, KB3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark. E-mail at-h{at}rh.dk
Objective— The aim of this study was to investigate whether the M235T polymorphism in the angiotensinogen gene was associated with angiotensinogen levels, systolic and diastolic blood pressure, hypertension, and risk of ischemic cardiovascular disease in different ethnic populations.
Methods and Results— One hundred twenty-seven studies published between January 1992 and March 2002 examining the association of angiotensinogen gene polymorphisms with the above-mentioned end points were selected. Pooled effect sizes and Mantel-Haenszel odds ratios were calculated using Review Manager. In white subjects, genotype was associated with a stepwise increase in plasma angiotensinogen levels of 5% (95% CI, 2% to 8%; P=0.0004) in MT heterozygotes and 11% (7% to 15%; P<0.00001) in TT homozygotes compared with MM individuals. Correspondingly, genotype was associated with a stepwise increase in aggregated odds ratio for hypertension of 1.08 (95% CI, 1.01 to 1.15) in MT individuals and 1.19 (1.10 to 1.30) in TT individuals in white subjects and of 1.29 (95% CI, 0.96 to 1.74) and 1.60 (1.19 to 2.15) in Asian subjects. M235T genotype did not predict systolic or diastolic blood pressure or risk of ischemic heart disease or myocardial infarction in either ethnic group.
Conclusions— Angiotensinogen M235T genotype was associated with a stepwise increase in angiotensinogen levels in white subjects and a corresponding increase in risk of hypertension in both white and Asian subjects.
Key Words: meta-analysis • blood pressure • genetics • hypertension • cardiovascular disease
This article has been cited by other articles:
 |
|
 |
|
  J. P. A. Ioannidis Effect of Formal Statistical Significance on the Credibility of Observational Associations Am. J. Epidemiol., August 15, 2008; 168(4): 374 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. van der Net, J. van Etten, M. Yazdanpanah, G. M. Dallinga-Thie, J. J.P. Kastelein, J. C. Defesche, R. P. Koopmans, E. W. Steyerberg, and E. J.G. Sijbrands Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia Eur. Heart J., June 1, 2008; 29(11): 1370 - 1376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. V. Pereira, A. C.F. Nunes, M. Rudnicki, Y. Yamada, A. C. Pereira, and J. E. Krieger Meta-Analysis of the Association of 4 Angiotensinogen Polymorphisms With Essential Hypertension: A Role Beyond M235T? Hypertension, March 1, 2008; 51(3): 778 - 783. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Baker, T. Rahman, D. Hall, P. J Avery, B. M Mayosi, J. M C Connell, M. Farrall, H. Watkins, and B. Keavney The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: A possible explanation for heterogeneity in genetic association studies of AGT and hypertension Int. J. Epidemiol., December 1, 2007; 36(6): 1356 - 1362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Deng Genetic basis of polygenic hypertension Hum. Mol. Genet., October 15, 2007; 16(R2): R195 - R202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M J E van Rijn, M J Bos, A Isaacs, M Yazdanpanah, A Arias-Vasquez, B H C. Stricker, O H Klungel, B A Oostra, P J Koudstaal, J C Witteman, et al. Polymorphisms of the renin angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology J. Neurol. Neurosurg. Psychiatry, October 1, 2007; 78(10): 1083 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-Q. Xu, Z. Ye, F. B. Hu, and L. He Quantitative Assessment of the Effect of Angiotensinogen Gene Polymorphisms on the Risk of Coronary Heart Disease Circulation, September 18, 2007; 116(12): 1356 - 1366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kitsios and E. Zintzaras Genetic Variation associated with Ischemic Heart Failure: A HuGE Review and Meta-Analysis Am. J. Epidemiol., September 15, 2007; 166(6): 619 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Marciante, J. C. Bis, M. J. Rieder, A. P. Reiner, T. Lumley, S. A. Monks, C. Kooperberg, C. Carlson, S. R. Heckbert, and B. M. Psaty Renin-Angiotensin System Haplotypes and the Risk of Myocardial Infarction and Stroke in Pharmacologically Treated Hypertensive Patients Am. J. Epidemiol., July 1, 2007; 166(1): 19 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Arnett, A. E. Baird, R. A. Barkley, C. T. Basson, E. Boerwinkle, S. K. Ganesh, D. M. Herrington, Y. Hong, C. Jaquish, D. A. McDermott, et al. Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, June 5, 2007; 115(22): 2878 - 2901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Morgan, H. M. Krumholz, R. P. Lifton, and J. A. Spertus Nonvalidation of Reported Genetic Risk Factors for Acute Coronary Syndrome in a Large-Scale Replication Study JAMA, April 11, 2007; 297(14): 1551 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Dickson, M. B. Zimmerman, K. Rahmouni, and C. D. Sigmund The -20 and -217 Promoter Variants Dominate Differential Angiotensinogen Haplotype Regulation in Angiotensinogen-Expressing Cells Hypertension, March 1, 2007; 49(3): 631 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Goldenberg, A. J. Moss, D. Ryan, S. McNitt, S. W. Eberly, and W. Zareba Polymorphism in the Angiotensinogen Gene, Hypertension, and Ethnic Differences in the Risk of Recurrent Coronary Events Hypertension, October 1, 2006; 48(4): 693 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Castellano Geographic Ancestry, Angiotensinogen Gene Polymorphism, and Cardiovascular Risk Hypertension, October 1, 2006; 48(4): 562 - 563. [Full Text] [PDF]
|
|
|
|
|
|
M. E. Dickson and C. D. Sigmund Genetic Basis of Hypertension: Revisiting Angiotensinogen Hypertension, July 1, 2006; 48(1): 14 - 20. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Skov, J. K. Madsen, H. E. Hansen, L. Zagato, E. Frandsen, G. Bianchi, and M. J. Mulvany Renal Haemodynamics are not Related to Genotypes in Offspring of Parents with Essential Hypertension Journal of Renin-Angiotensin-Aldosterone System, March 1, 2006; 7(1): 47 - 55. [Abstract] [PDF]
|
|
|
|
|
|
T. A. Trikalinos, G. Salanti, M. J. Khoury, and J. P. A. Ioannidis Impact of Violations and Deviations in Hardy-Weinberg Equilibrium on Postulated Gene-Disease Associations Am. J. Epidemiol., February 15, 2006; 163(4): 300 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bamshad Genetic Influences on Health: Does Race Matter? JAMA, August 24, 2005; 294(8): 937 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C.M. Jansen, E. S. van Aalst-Cohen, M. W.T. Tanck, S. Cheng, M. R. Fontecha, J. Li, J. C. Defesche, and J. J.P. Kastelein Genetic Determinants of Cardiovascular Disease Risk in Familial Hypercholesterolemia Arterioscler. Thromb. Vasc. Biol., July 1, 2005; 25(7): 1475 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G D Kolovou, K K Anagnostopoulou, and D V Cokkinos Pathophysiology of dyslipidaemia in the metabolic syndrome Postgrad. Med. J., June 1, 2005; 81(956): 358 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-Y. Hsieh, C.-C. Chang, F.-J. Tsai, C.-M. Hsu, C.-C. Lin, and C.-H. Tsai Angiotensin I-converting enzyme ACE 2350*G and ACE-240*T-related genotypes and alleles are associated with higher susceptibility to endometriosis Mol. Hum. Reprod., January 1, 2005; 11(1): 11 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. Luft Geneticism of Essential Hypertension Hypertension, June 1, 2004; 43(6): 1155 - 1159. [Full Text] [PDF]
|
|