Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:972-980
Published online before print January 9, 2003, doi: 10.1161/01.ATV.0000054661.21499.FB
Published online before print January 9, 2003, doi: 10.1161/01.ATV.0000054661.21499.FB
© 2003 American Heart Association, Inc.
ATVB In Focus |
ABCA1-Deficient Mice
Insights Into the Role of Monocyte Lipid Efflux in HDL Formation and Inflammation
From Pfizer Global Research and Development, Department of Cardiovascular and Metabolic Diseases, Groton, Conn.
Correspondence to Robert J. Aiello or Omar L. Francone, Pfizer Global Research and Development, Department of Cardiovascular and Metabolic Diseases, Eastern Point Road, Groton, CT 06340. E-mail Robert_J_Aiello{at}groton.pfizer.com or Omar_L_Francone@groton.pfizer.com
Series Editor: Alan R. Tall
ATVB In Focus Role of ABCA1 in Cellular Cholesterol Efflux and Reverse Cholesterol Transport
Previous Brief Reviews in this Series:
•Yancy PG, Bortnick AE, Kellner-Weibel G, de la Llera-Moya M, Phillips MC, Rothblat GH. Importance of different pathways of cellular cholesterol efflux. 2003;23:712–719.
•Oram JF. HDL Apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol. 2003;23:720–727.
•Joyce C, Freeman L, Brewer HB Jr, Sanatamarina-Fojo S. Study of ABCA1 function in transgenic mice. 2003;23:965–971.
Studies with ATP-binding cassette transporter (ABCA1)–deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on atherosclerosis.
Key Words: Tangier disease • ATP-binding cassette transporter A1 • cholesterol efflux • HDL • macrophages • atherosclerosis
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