This Article Full Text Full Text (PDF) All Versions of this Article: 23/6/940    most recent 01.ATV.0000066878.27340.22v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yin, Y.-J. Articles by Bar-Shavit, R. Search for Related Content PubMed PubMed Citation Articles by Yin, Y.-J. Articles by Bar-Shavit, R. Related Collections Angiogenesis Pathophysiology Thrombin Signal transduction Extracellular Mediators in Atherosclerosis and Thrombosis

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:940.)
© 2003 American Heart Association, Inc.

ATVB in Focus

Human Protease-Activated Receptor 1 Expression in Malignant Epithelia

A Role in Invasiveness

Yong-Jun Yin; Zaidoun Salah; Sorina Grisaru-Granovsky; Irit Cohen; Sharona Cohen Even-Ram; Myriam Maoz; Beatrice Uziely; Tamar Peretz; Rachel Bar-Shavit

From the Department of Oncology Hadassah-University Hospital, Jerusalem, Israel.

Correspondence to Rachel Bar-Shavit, PhD, Department of Oncology, Hadassah-University Hospital, POB 12000, Jerusalem 91120, Israel. E-mail barshav{at}md.huji.ac.il

Series Editor: Marschall S. Runge
ATVB In Focus Extracellular Mediators in Atherosclerosis and Thrombosis

Previous Brief Reviews in this Series:

•Brasier AR, Recinos A III, Eledrisi MS. Vascular inflammation and the renin-angiotensin system. 2002;22:1257–1266.
•Moser M, Patterson C. Thrombin and vascular development: a sticky subject. 2003;23:922–930.
•Major CD, Santulli RJ, Derian CK, Andrade-Gordon P. Extracellular mediators in atherosclerosis and thrombosis: lessons from thrombin receptor knockout mice. 2003;23:931–939.

While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands.

Key Words: PAR1 • epithelia • invasion • metastasis • angiogenesis

This article has been cited by other articles:

				K. L. Elzer, D. A. Heitzman, M. I. Chernin, and J. F. Novak Differential Effects of Serine Proteases on the Migration of Normal and Tumor Cells: Implications for Tumor Microenvironment Integr Cancer Ther, December 1, 2008; 7(4): 282 - 294. [Abstract] [PDF]

				H. H. Versteeg, F. Schaffner, M. Kerver, L. G. Ellies, P. Andrade-Gordon, B. M. Mueller, and W. Ruf Protease-Activated Receptor (PAR) 2, but not PAR1, Signaling Promotes the Development of Mammary Adenocarcinoma in Polyoma Middle T Mice Cancer Res., September 1, 2008; 68(17): 7219 - 7227. [Abstract] [Full Text] [PDF]

				Z. Salah, M. Maoz, G. Pizov, and R. Bar-Shavit Transcriptional Regulation of Human Protease-Activated Receptor 1: A Role for the Early Growth Response-1 Protein in Prostate Cancer Cancer Res., October 15, 2007; 67(20): 9835 - 9843. [Abstract] [Full Text] [PDF]

				E. Arciniegas, M. G. Frid, I. S. Douglas, and K. R. Stenmark Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L1 - L8. [Abstract] [Full Text] [PDF]

				P. Arora, T. K. Ricks, and J. Trejo Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer J. Cell Sci., March 15, 2007; 120(6): 921 - 928. [Abstract] [Full Text] [PDF]

				Z. Salah, M. Maoz, E. Pokroy, M. Lotem, R. Bar-Shavit, and B. Uziely Protease-Activated Receptor-1 (hPar1), A Survival Factor Eliciting Tumor Progression Mol. Cancer Res., March 1, 2007; 5(3): 229 - 240. [Abstract] [Full Text] [PDF]

				T. Goerge, A. Barg, E.-M. Schnaeker, B. Poppelmann, V. Shpacovitch, A. Rattenholl, C. Maaser, T. A. Luger, M. Steinhoff, and S. W. Schneider Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation. Cancer Res., August 1, 2006; 66(15): 7766 - 7774. [Abstract] [Full Text] [PDF]

				Y.-J. Yin, V. Katz, Z. Salah, M. Maoz, I. Cohen, B. Uziely, H. Turm, S. Grisaru-Granovsky, H. Suzuki, and R. Bar-Shavit Mammary Gland Tissue Targeted Overexpression of Human Protease-Activated Receptor 1 Reveals a Novel Link to {beta}-Catenin Stabilization. Cancer Res., May 15, 2006; 66(10): 5224 - 5233. [Abstract] [Full Text] [PDF]

				M. Belting, J. Ahamed, and W. Ruf Signaling of the Tissue Factor Coagulation Pathway in Angiogenesis and Cancer Arterioscler Thromb Vasc Biol, August 1, 2005; 25(8): 1545 - 1550. [Abstract] [Full Text] [PDF]

				L. Ma, R. Perini, W. McKnight, M. Dicay, A. Klein, M. D. Hollenberg, and J. L. Wallace Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets PNAS, January 4, 2005; 102(1): 216 - 220. [Abstract] [Full Text] [PDF]

				J. Ahamed and W. Ruf Protease-activated Receptor 2-dependent Phosphorylation of the Tissue Factor Cytoplasmic Domain J. Biol. Chem., May 28, 2004; 279(22): 23038 - 23044. [Abstract] [Full Text] [PDF]