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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:922.)
© 2003 American Heart Association, Inc.

ATVB in Focus

Thrombin and Vascular Development

A Sticky Subject

Martin Moser; Cam Patterson

From the Carolina Cardiovascular Biology Center and Departments of Medicine, Pharmacology, and Cell and Developmental Biology, University of North Carolina, Chapel Hill.

Correspondence to Cam Patterson, MD, Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 5.109C Neurosciences Bldg, Chapel Hill, NC 27599-7126. E-mail cpatters{at}med.unc.edu

Series Editor: Marschall S. Runge
ATVB In Focus Extracellular Mediators in Atherosclerosis and Thrombosis

Previous Brief Review in this Series:

•Brasier AR, Recinos A III, Eledrisi MS. Vascular inflammation and the renin-angiotensin system. 2002;22:1257–1266.

Formation of the vasculature is an essential step in embryogenesis. It was observed decades ago that the vasculature and the intravascular blood compartment, which uses the former as a means of transportation, develop in a close spatial and temporal relationship. In this review, we discuss the role of the blood coagulation system as a tool to coordinate angiogenesis. Several mouse models lacking coagulation factors result in impaired thrombin generation and display a phenotype of disturbed cardiovascular development. Similar phenotypes are observed in mouse models of impaired thrombin binding to its cellular receptor, protease-activated receptor-1, or of disrupted signaling via G proteins. Most interestingly, the available data provide evidence that thrombin signaling in vascular development cannot be explained by a model based only on the classic extrinsic and intrinsic coagulation pathways. Because angiogenesis in adults follows the same signaling patterns as angiogenesis in embryos, it is important to learn about these pathways, hoping that they may serve as therapeutic targets in cardiovascular disease.

Key Words: thrombin • angiogenesis • vascular development • thrombosis • hemostasis

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