Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:434-439
Published online before print January 30, 2003, doi: 10.1161/01.ATV.0000058402.34138.11
Published online before print January 30, 2003, doi: 10.1161/01.ATV.0000058402.34138.11
© 2003 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Obesity and Systemic Oxidative Stress
Clinical Correlates of Oxidative Stress in The Framingham Study
From the Evans Memorial Department of Medicine (J.F.K. R.S.V., P.W.F.W., J.A.V., E.J.B.), Whitaker Cardiovascular Institute (J.F.K., I.L., J.A.V.), and Department of Preventive Medicine (R.S.V., E.J.B.), Boston University School of Medicine; Department of Epidemiology and Biostatistics (J.M.M.), Boston University School of Public Health; and the National Heart, Lung, and Blood Institute Framingham Study (M.G.L., R.S.V., P.W.F.W., D.C., J.M.M., P.S., E.J.B.), Framingham, MA.
Correspondence to J.F. Keaney, Jr, Boston University School of Medicine, Whitaker Cardiovascular Institute, 715 Albany St, Rm W507, Boston, MA 02118. E-mail jkeaney{at}bu.edu
Objective— To determine the clinical conditions associated with systemic oxidative stress in a community-based cohort. Information regarding cardiovascular risk factors associated with systemic oxidative stress has largely been derived from highly selected samples with advanced stages of vascular disease. Thus, it has been difficult to evaluate the relative contribution of each cardiovascular risk factor to systemic oxidative stress and to determine whether such risk factors act independently and are applicable to the general population.
Methods and Results— We examined 2828 subjects from the Framingham Heart Study and measured urinary creatinine–indexed levels of 8-epi-PGF2
as a marker of systemic oxidative stress. Age- and sex-adjusted multivariable regression models were used to assess clinical correlates of oxidative stress. In age- and sex-adjusted models, increased urinary creatinine–indexed 8-epi-PGF2 levels were positively associated with female sex, hypertension treatment, smoking, diabetes, blood glucose, body mass index, and a history of cardiovascular disease. In contrast, age and total cholesterol were negatively correlated with urinary creatinine–indexed 8-epi-PGF2 levels. After adjustment for several covariates, decreasing age and total/HDL cholesterol ratio, sex, smoking, body mass index, blood glucose, and cardiovascular disease remained associated with urinary 8-epi-PGF2 levels.
Conclusions— Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2 levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease.
Key Words: oxidative stress • isoprostanes • diabetes • obesity • cardiovascular disease
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J. A. Vita, J. F. Keaney Jr, M. G. Larson, M. J. Keyes, J. M. Massaro, I. Lipinska, B. T. Lehman, S. Fan, E. Osypiuk, P. W.F. Wilson, et al. Brachial Artery Vasodilator Function and Systemic Inflammation in the Framingham Offspring Study Circulation, December 7, 2004; 110(23): 3604 - 3609. [Abstract] [Full Text] [PDF]
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M. Juonala, J. S.A. Viikari, T. Laitinen, J. Marniemi, H. Helenius, T. Ronnemaa, and O. T. Raitakari Interrelations Between Brachial Endothelial Function and Carotid Intima-Media Thickness in Young Adults: The Cardiovascular Risk in Young Finns Study Circulation, November 2, 2004; 110(18): 2918 - 2923. [Abstract] [Full Text] [PDF]
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B. Hansel, P. Giral, E. Nobecourt, S. Chantepie, E. Bruckert, M. J. Chapman, and A. Kontush Metabolic Syndrome Is Associated with Elevated Oxidative Stress and Dysfunctional Dense High-Density Lipoprotein Particles Displaying Impaired Antioxidative Activity J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4963 - 4971. [Abstract] [Full Text] [PDF]
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R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]
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F.-P. Xu, M.-S. Chen, Y.-Z. Wang, Q. Yi, S.-B. Lin, A. F. Chen, and J.-D. Luo Leptin Induces Hypertrophy via Endothelin-1-Reactive Oxygen Species Pathway in Cultured Neonatal Rat Cardiomyocytes Circulation, September 7, 2004; 110(10): 1269 - 1275. [Abstract] [Full Text] [PDF]
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S. Mustafa, T. Vukovich, T. Prikoszovich, C. Winzer, B. Schneider, H. Esterbauer, O. Wagner, and A. Kautzky-Willer Haptoglobin Phenotype and Gestational Diabetes Diabetes Care, September 1, 2004; 27(9): 2103 - 2107. [Abstract] [Full Text] [PDF]
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H. Shibata, T. Nabika, H. Moriyama, J. Masuda, and S. Kobayashi Correlation of NO Metabolites and 8-Iso-Prostaglandin F2a With Periventricular Hyperintensity Severity Arterioscler. Thromb. Vasc. Biol., September 1, 2004; 24(9): 1659 - 1663. [Abstract] [Full Text] [PDF]
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C. Vassalle, M. G. Andreassi, E. Schwedhelm, R. Maas, R. H. Boger, J. Brummer, J. Berger, A. Bartling, H. Lenzen, D. Tsikas, et al. 8-Iso-Prostaglandin F2{alpha} as a Risk Marker in Patients With Coronary Heart Disease * Response Circulation, August 3, 2004; 110(5): e49 - e50. [Full Text] [PDF]
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 G. Xing, T. Shimosawa, T. Ogihara, H. Matsui, K. Itakura, X. Qingyou, T. Asano, K. Ando, and T. Fujita Angiotensin II-Induced Insulin Resistance Is Enhanced in Adrenomedullin-Deficient Mice Endocrinology, August 1, 2004; 145(8): 3647 - 3651. [Abstract] [Full Text] [PDF]
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N. C. Ward, J. Rivera, J. Hodgson, I. B. Puddey, L. J. Beilin, J. R. Falck, and K. D. Croft Urinary 20-Hydroxyeicosatetraenoic Acid Is Associated With Endothelial Dysfunction in Humans Circulation, July 27, 2004; 110(4): 438 - 443. [Abstract] [Full Text] [PDF]
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T. Matsumoto, H. Takashima, N. Ohira, Y. Tarutani, Y. Yasuda, T. Yamane, S. Matsuo, and M. Horie Plasma level of oxidized low-density lipoprotein is an independent determinant of coronary macrovasomotor and microvasomotor responses induced by bradykinin J. Am. Coll. Cardiol., July 21, 2004; 44(2): 451 - 457. [Abstract] [Full Text] [PDF]
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P. M Ridker, N. J. Brown, D. E. Vaughan, D. G. Harrison, and J. L. Mehta Established and Emerging Plasma Biomarkers in the Prediction of First Atherothrombotic Events Circulation, June 29, 2004; 109(25_suppl_1): IV-6 - IV-19. [Full Text] [PDF]
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J. Gomez-Ambrosi, J. Salvador, and G. Fruhbeck Is hyperleptinemia involved in the development of age-related lens opacities? Am. J. Clinical Nutrition, May 1, 2004; 79(5): 888 - 889. [Full Text] [PDF]
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C. S. Fox, L. Sullivan, R. B. D'Agostino Sr, and P. W.F. Wilson The Significant Effect of Diabetes Duration on Coronary Heart Disease Mortality: The Framingham Heart Study Diabetes Care, March 1, 2004; 27(3): 704 - 708. [Abstract] [Full Text] [PDF]
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 J. T. Lane Microalbuminuria as a marker of cardiovascular and renal risk in type 2 diabetes mellitus: a temporal perspective Am J Physiol Renal Physiol, March 1, 2004; 286(3): F442 - F450. [Abstract] [Full Text] [PDF]
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T. L. Goodfriend and D. A. Calhoun Resistant Hypertension, Obesity, Sleep Apnea, and Aldosterone: Theory and Therapy Hypertension, March 1, 2004; 43(3): 518 - 524. [Abstract] [Full Text] [PDF]
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E. Schwedhelm, A. Bartling, H. Lenzen, D. Tsikas, R. Maas, J. Brummer, F.-M. Gutzki, J. Berger, J. C. Frolich, and R. H. Boger Urinary 8-iso-Prostaglandin F2{alpha} as a Risk Marker in Patients With Coronary Heart Disease: A Matched Case-Control Study Circulation, February 24, 2004; 109(7): 843 - 848. [Abstract] [Full Text] [PDF]
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T. L. Goodfriend, D. L. Ball, B. M. Egan, W. B. Campbell, and K. Nithipatikom Epoxy-Keto Derivative of Linoleic Acid Stimulates Aldosterone Secretion Hypertension, February 1, 2004; 43(2): 358 - 363. [Abstract] [Full Text] [PDF]
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M. E. Widlansky, D. T. Price, N. Gokce, R. T. Eberhardt, S. J. Duffy, M. Holbrook, C. Maxwell, J. Palmisano, J. F. Keaney Jr, J. D. Morrow, et al. Short- and Long-Term COX-2 Inhibition Reverses Endothelial Dysfunction in Patients With Hypertension Hypertension, September 1, 2003; 42(3): 310 - 315. [Abstract] [Full Text] [PDF]
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J. V. Higdon and B. Frei Obesity and Oxidative Stress: A Direct Link to CVD? Arterioscler. Thromb. Vasc. Biol., March 1, 2003; 23(3): 365 - 367. [Full Text] [PDF]
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J. D. Morrow Is Oxidant Stress a Connection Between Obesity and Atherosclerosis? Arterioscler. Thromb. Vasc. Biol., March 1, 2003; 23(3): 368 - 370. [Full Text] [PDF]
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