This Article Full Text Full Text (PDF) All Versions of this Article: 23/12/2247    most recent 01.ATV.0000102924.11767.8dv1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Engström, G. Articles by Lindgärde, F. Search for Related Content PubMed PubMed Citation Articles by Engström, G. Articles by Lindgärde, F. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Heart Attack Related Collections Behavioral/psychosocial - treatment Behavioral/psychosocial - CV surgery Acute Cerebral Hemorrhage

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:2247.)
© 2003 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Inflammation-Sensitive Plasma Proteins and Incidence of Myocardial Infarction in Men With Low Cardiovascular Risk

Gunnar Engström; Lars Stavenow; Bo Hedblad; Peter Lind; Patrik Tydén; Lars Janzon; Folke Lindgärde

From the Departments of Community Medicine (G.E., B.H., P.T., L.J.), Internal Medicine (L.S., P.L.), Vascular Diseases (F.L.), and Cardiology (P.T.), Malmö University Hospital, Malmö, Sweden.

Correspondence to Gunnar Engström, MD, PhD, Department of Community Medicine, Malmö University Hospital, S-20502 Malmö, Sweden. E-mail Gunnar.Engstrom{at}smi.mas.lu.se

Objective— Myocardial infarction (MI) is sometimes experienced by individuals without any traditional risk factor. This prospective study explored whether incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and serum lipids is related to inflammation-sensitive plasma proteins (ISPs).

Methods and Results— Five ISPs (1-antitrypsin, haptoglobin, ceruloplasmin, fibrinogen, orosomucoid) were analyzed in 6075 men, 47±3.6 years old. A low-risk group (no traditional risk factor, n=1108) and a high-risk group (2 major risk factors, n=1011) were defined. Incidence of MI (n=227) was monitored over 18.1±4.3 years of follow-up. In the low-risk group, the age-adjusted relative risks (RRs) were 1.00 (reference), 1.9 (95% CI, 0.8 to 4.2), 1.8 (95% CI, 0.6 to 5.4), and 2.9 (95% CI, 1.05 to 8.1), respectively, for men with 0, 1, 2 and 3 ISPs in the top quartile (trend: P=0.03). In this group, the increased risk was observed only after 10 years of follow-up. In the high-risk group, the age-adjusted RRs were 1.00, 1.4 (95% CI, 0.9 to 2.2), 1.9 (95% CI, 1.2 to 3.1), and 2.0 (95% CI, 1.3 to 3.1), respectively, for men with 0, 1, 2, and 3 ISPs in the top quartile (trend: P=0.0004).

Conclusion— Incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and lipids was related to ISPs. The causes for this relationship remain to be explored.

Key Words: myocardial infarction • inflammation • epidemiology • risk factors

This article has been cited by other articles:

				C Turesson, R L McClelland, T J H Christianson, and E L Matteson Severe extra-articular disease manifestations are associated with an increased risk of first ever cardiovascular events in patients with rheumatoid arthritis Ann Rheum Dis, January 1, 2007; 66(1): 70 - 75. [Abstract] [Full Text] [PDF]

				V. S Malik, M. B Schulze, and F. B Hu Intake of sugar-sweetened beverages and weight gain: a systematic review. Am. J. Clinical Nutrition, August 1, 2006; 84(2): 274 - 288. [Abstract] [Full Text] [PDF]

				G. Engstrom The role of inflammation for heart disease risk cannot be determined by correlations between C-reactive protein and risk factors. Arch Intern Med, May 8, 2006; 166(9): 1040 - 1040. [Full Text] [PDF]

				G. Engstrom, B. Hedblad, M. Rosvall, L. Janzon, and F. Lindgarde Occupation, Marital Status, and Low-Grade Inflammation: Mutual Confounding or Independent Cardiovascular Risk Factors? Arterioscler Thromb Vasc Biol, March 1, 2006; 26(3): 643 - 648. [Abstract] [Full Text] [PDF]

				A. D. Karelis, M. Faraj, J.-P. Bastard, D. H. St-Pierre, M. Brochu, D. Prud'homme, and R. Rabasa-Lhoret The Metabolically Healthy but Obese Individual Presents a Favorable Inflammation Profile J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4145 - 4150. [Abstract] [Full Text] [PDF]

				V. M. Miller, G. Rodgers, J. A. Charlesworth, B. Kirkland, S. R. Severson, T. E. Rasmussen, M. Yagubyan, J. C. Rodgers, F. R. Cockerill III, R. L. Folk, et al. Evidence of nanobacterial-like structures in calcified human arteries and cardiac valves Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1115 - H1124. [Abstract] [Full Text] [PDF]

				G. Engstrom, B. Hedblad, L. Stavenow, S. Jonsson, P. Lind, L. Janzon, and F. Lindgarde Incidence of Obesity-Associated Cardiovascular Disease Is Related to Inflammation-Sensitive Plasma Proteins: A Population-Based Cohort Study Arterioscler Thromb Vasc Biol, August 1, 2004; 24(8): 1498 - 1502. [Abstract] [Full Text] [PDF]