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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:2138.)
© 2003 American Heart Association, Inc.

Brief Reviews

Coronary Vessel Development

A Unique Form of Vasculogenesis

Aya M. Wada; Spencer G. Willet; David Bader

From the Stahlman Cardiovascular Laboratories, Program for Developmental Biology, Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tenn.

Correspondence to David Bader, 348 Preston Research Bldg, Nashville, TN 37232. E-mail david.bader{at}vanderbilt.edu

Development of the coronary vascular system is an interesting model in developmental biology with major implications for the clinical setting. Although coronary vessel development is a form of vasculogenesis followed by angiogenesis, this system uses several unique developmental processes not observed in the formation of other blood vessels. This review summarizes the literature that describes the development of the coronary system, highlighting the unique aspects of coronary vessel development. It should be noted that many of the basic mechanisms that govern vasculogenesis in other systems have not been analyzed in coronary vessel development. In addition, we present recent advances in the field that uncover the basic mechanisms regulating the generation of these blood vessels and identify areas in need of additional studies.

Key Words: coronary vessels • development • embryology • heart

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