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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:2131.)
© 2003 American Heart Association, Inc.

Brief Reviews

Platelets in Inflammation and Thrombosis

Denisa D. Wagner; Peter C. Burger

From The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Mass.

Correspondence to Denisa D. Wagner, The Center for Blood Research, 800 Huntington Ave, Boston, MA 02115. E-mail wagner{at}cbr.med.harvard.edu

For many years it has been known that platelets play an important role in thrombosis and hemostasis. In recent times, however, it has become evident that platelets also have relevant functions in inflammation. It was shown that thrombosis and inflammation share several key molecular mechanisms and in fact are 2 intrinsically linked processes. In this review, we intend to give a short overview with emphasis on work stemming from our laboratory.

Key Words: platelets • inflammation • thrombosis • atherosclerosis • hemostasis

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