Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:85-89
Published online before print December 2, 2002, doi: 10.1161/01.ATV.0000048856.22331.50
Published online before print December 2, 2002, doi: 10.1161/01.ATV.0000048856.22331.50
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© 2003 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Association of Hypoadiponectinemia With Coronary Artery Disease in Men
From the Department of Internal Medicine and Molecular Science (M.K., S.K., N.O., Y.A., Y.O., I.S., H.H., T.N., T.F., Y.M.), Graduate School of Medicine, Osaka University; the Department of Cardiology (S.S.), Rinku General Medical Center; the Department of Cardiology (T.K.), National Hospital Kure Medical Center; and the Department of Cardiology (S.M.), Toyonaka Municipal Hospital, Osaka, Japan.
Correspondence to Shinji Kihara, MD, PhD, Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2, Yamada-oka, Suita, Osaka, 565-0871, Japan. E-mail kihara{at}imed2.med.osaka-u.ac.jp
Background— Adiponectin is an adipocyte-derived plasma protein that accumulates in the injured artery and has potential antiatherogenic properties. This study was designed to determine whether a decreased plasma adiponectin level (hypoadiponectinemia) can be independently associated with the prevalence of coronary artery disease (CAD).
Methods and Results— The consecutive 225 male patients were enrolled from inpatients who underwent coronary angiography. Voluntary blood donors (n=225) matched for age served as controls. Plasma adiponectin levels in the CAD patients were significantly lower than those in the control subjects. Multiple logistic regression analysis including plasma adiponectin level, diabetes mellitus, dyslipidemia, hypertension, smoking habits, and body mass index revealed that hypoadiponectinemia was significantly and independently correlated with CAD (P<0.0088). The entire study population was categorized in quartiles based on the distribution of plasma adiponectin levels. The interquartile cutoff points were 4.0, 5.5, and 7.0 µg/mL. The multivariate-adjusted odds ratios for CAD in the first, second, and third quartiles were 2.051 (95% confidence interval [CI], 1.288 to 4.951), 1.221 (95% CI, 0.684 to2.186), and 0.749 (95%CI, 0.392 to 1.418), respectively.
Conclusions— Male patients with hypoadiponectinemia (<4.0 µg/mL) had a significant 2-fold increase in CAD prevalence, independent of well-known CAD risk factors.
Key Words: adiponectin • risk factor • coronary artery disease
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