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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:26.)
© 2003 American Heart Association, Inc.

Brief Reviews

Functional Interplay Between Angiotensin II and Nitric Oxide

Cyclic GMP as a Key Mediator

Chen Yan; Dongsoo Kim; Toru Aizawa; Bradford C. Berk

From the Center for Cardiovascular Research (C.Y., T.A., B.C.B.), University of Rochester, Rochester, NY, and the Department of Cardiology (D.K.), Yong Dong Severance Hospital, Yonsei University, Seoul, Korea.

Correspondence to Bradford C. Berk, MD, PhD, Cardiology Unit, Box 679, 601 Elmwood Ave, Rochester, NY 14642. E-mail Bradford_Berk{at}urmc.rochester.edu

Angiotensin II (Ang II) and nitric oxide (NO) signaling pathways mutually regulate each other by multiple mechanisms. Ang II regulates the expression of NO synthase and NO production, whereas NO downregulates the Ang II type I (AT1) receptor. In addition, downstream effectors of Ang II and NO signaling pathways also interact with each other. A feedback mechanism between Ang II and NO is critical for normal vascular structure and function. Imbalance of Ang II and NO has been implicated in the pathophysiology of many vascular diseases. In this review, we focus on the diverse ways in which Ang II and NO interact and the importance of the balance between the signaling pathways activated by these mediators.

Key Words: nitric oxide • angiotensin II • signaling pathways

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