Published online before print May 9, 2002, doi: 10.1161/01.ATV.0000021150.63480.CD
© 2002 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Circulating Oxidized LDL Is Associated With Subclinical Atherosclerosis Development and Inflammatory Cytokines (AIR Study)
From The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Göteborg University, Gothenburg, Sweden.
Address correspondence to Dr. Johannes Hulthe, The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Gothenburg, SE-41345 Sweden. E-mail johannes.hulthe{at}wlab.wall.gu.se
Objective— Circulating oxidized LDL (Ox-LDL) is associated with clinical manifestations of atherosclerosis. However, no previous study has examined the relationship between subclinical atherosclerosis and Ox-LDL. The aims of the present study were to investigate the relationship between clinically silent ultrasound-assessed atherosclerotic changes in the carotid and femoral arteries and Ox-LDL and to explore the relationship between Ox-LDL, C-reactive protein, and the inflammatory cytokines interleukin-6 and tumor necrosis factor-
.
Methods and Results— The study group (n=391) consisted of clinically healthy, 58-year-old men recruited from the general population. Ox-LDL was measured by using a specific monoclonal antibody, mAb-4E6. The results showed that Ox-LDL was related to intima-media thickness and plaque occurrence in the carotid and femoral arteries. In addition, Ox-LDL was associated with tumor necrosis factor- and C-reactive protein. Circulating Ox-LDL was also associated with LDL cholesterol but not with blood pressure or smoking. When adjusting for other risk factors, both LDL cholesterol and Ox-LDL seemed to be independent predictors of plaque occurrence in the carotid and femoral arteries (odds ratios for quintile 5 versus quintile 1 were 2.17, P=0.049 and 2.25, P=0.050, for LDL cholesterol and Ox-LDL, respectively).
Conclusions— Ox-LDL was associated with both subclinical atherosclerosis and inflammatory variables, supporting the concept that oxidatively modified LDL may play a major role in atherosclerosis development, although no causality can be shown in this cross-sectional study.
Key Words: oxidized LDL • atherosclerosis • intima-media thickness • plaque • inflammation
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