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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:342.)
© 2002 American Heart Association, Inc.

Thrombosis

Influence of Anatomical Location on Arterial Thrombosis

Krzysztof Karnicki^*; Erzsebet Komorowicz^*; David N. Fass; Whyte G. Owen; Robert D. McBane, II

From the Division of Cardiovascular Medicine (R.D.M.) and Section of Hematology Research (K.K., E.K., D.N.F., W.G.O, R.D.M.), Mayo Clinic and Foundation for Education and Research, Rochester, Minn; and Department of Medical Biochemistry (E.K.), Semmelweis University, Budapest, Hungary.

Address correspondence to Robert D. McBane, II, MD, Division of Cardiovascular Medicine, Mayo Clinic and Foundation for Education and Research, 200 First St SW, Rochester, MN 55905. E-mail mcbane.robert{at}mayo.edu

Atherosclerosis manifests as a systemic disease with near global involvement of the named segments of the arterial tree. Acute thrombotic arterial occlusion, however, is not equally distributed. To evaluate intra-individual regional differences in arterial thrombogenicity, we compared ¹¹¹In-platelet deposition in porcine carotid and femoral arteries after a standardized crush injury. Within the unidirectional flow conditions of elastic carotid arteries, platelet deposition was more than 3-fold higher compared with predominantly muscular femoral arteries with triphasic arterial flow. To determine the influence of rheology on platelet deposition after crush injury, carotid arteries were transplanted into the femoral position and compared with the paired native carotid and femoral arteries. Similarly, femoral arteries transposed to the carotid position were compared with the paired native carotid artery. In each of these experiments, arterial transposition to a new anatomic location imparts a predilection for platelet deposition indigenous to the new location. In the controlled environment of two high-shear thrombin–independent and –dependent flow chambers, porcine carotid and femoral arterial substrates were indistinguishable from one another with respect to platelet deposition. Regional differences in arterial hemodynamics may account for substantial differences in thrombosis arising from deep arterial injury.

Key Words: arteries • thrombosis • platelets

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