This Article Full Text Full Text (PDF) All Versions of this Article: 22/10/1720    most recent 01.ATV.0000032133.12377.4Dv1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kammerer, C. M. Articles by VandeBerg, J. L. Search for Related Content PubMed PubMed Citation Articles by Kammerer, C. M. Articles by VandeBerg, J. L. Related Collections Lipids Animal models of human disease Genetics of cardiovascular disease

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1720.)
© 2002 American Heart Association, Inc.

Lipoproteins

Locus Controlling LDL Cholesterol Response to Dietary Cholesterol Is on Baboon Homologue of Human Chromosome 6

Candace M. Kammerer; David L. Rainwater; Laura A. Cox; Jennifer L. Schneider; Michael C. Mahaney; Jeffrey Rogers; John L. VandeBerg

From the Department of Human Genetics (C.M.K.), University of Pittsburgh, Pittsburgh, Pa; the Southwest Foundation for Biomedical Research (C.M.K., D.L.R., L.A.C., J.L.S., M.C.M., J.R., J.L.V.), San Antonio, Tex; and the Southwest National Primate Research Center (J.R., J.L.V.), San Antonio, Tex.

Correspondence to Candace M. Kammerer, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 De Soto St, Pittsburgh, PA 15261. E-mail ckammerer{at}hgen.pitt.edu

Abstract

Objective— Cholesterolemic responses to dietary lipids are known to be heritable, but the genes that may affect this response have yet to be identified. Using segregation analysis, we previously detected a potential quantitative trait locus (QTL) in baboons that influenced low density lipoprotein cholesterol response to dietary cholesterol. We performed linkage analyses to locate this QTL by using data on the baboon genetic linkage map.

Methods and Results— We obtained evidence for linkage of this potential QTL to the same locus (D6S311) on the baboon homologue of human chromosome 6 by using variance components and parametric linkage analysis methods (2-point lod scores 4.17 [genomic probability value 0.008] and 2.81 [genomic P=0.10], respectively). Linkage analyses of serum levels of apolipoprotein B dietary response, a correlated trait, also gave weak suggestive evidence of linkage to this chromosomal region (maximum 2-point lod score 1.91). Although the LPA locus is nearby, we found no evidence of linkage with LPA.

Conclusions— This report is the first to localize, in any primate species, a potential QTL that influences low density lipoprotein cholesterol response to dietary cholesterol.

Key Words: LDL • diet • linkage • baboons

This article has been cited by other articles:

				D. L. Rainwater, L. A. Cox, J. Rogers, J. L. VandeBerg, and M. C. Mahaney Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons J. Lipid Res., July 1, 2009; 50(7): 1420 - 1428. [Abstract] [Full Text] [PDF]

				A. Vinson, M. C. Mahaney, V. P. Diego, L. A. Cox, J. Rogers, J. L. VandeBerg, and D. L. Rainwater Genotype-by-diet effects on co-variation in Lp-PLA2 activity and LDL-cholesterol concentration in baboons fed an atherogenic diet J. Lipid Res., June 1, 2008; 49(6): 1295 - 1302. [Abstract] [Full Text] [PDF]

				V. L.M. Herrera, T. Didishvili, L. V. Lopez, R. H. Myers, and N. Ruiz-Opazo Genome-Wide Scan Identifies Novel QTLs for Cholesterol and LDL Levels in F2[Dahl RxS]-Intercross Rats Circ. Res., March 5, 2004; 94(4): 446 - 452. [Abstract] [Full Text] [PDF]

				C. M. Kammerer, D. L. Rainwater, J. L. Schneider, L. A. Cox, M. C. Mahaney, J. Rogers, and J. F. VandeBerg Two Loci Affect Angiotensin I-Converting Enzyme Activity in Baboons Hypertension, March 1, 2003; 41(3): 854 - 859. [Abstract] [Full Text] [PDF]