Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:21-27
doi: 10.1161/hq0102.102189
doi: 10.1161/hq0102.102189
© 2002 American Heart Association, Inc.
Vascular Biology |
Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury
From the Department of Medicine (K.S., B.L., D.S., L.L.H., L.V., K.K.G.), Division of Cardiology, the Winship Cancer Institute (T.L.C., J.N.W.), Division of Hematology/Oncology, and the Department of Biochemistry (J.D.L.), Emory University, Atlanta, Ga, and the Department of Veterinary Molecular Biology (M.T.Q.), Montana State University, Bozeman.
Correspondence to Kathy K. Griendling, Emory University, Division of Cardiology, 319 WMB, 1639 Pierce Dr, Atlanta, GA 30322. E-mail kgriend{at}emory.edu
Restenosis, a frequent complication of coronary angioplasty, is associated with increased superoxide (O2·-) production. Although the molecular identity of the responsible oxidase is unclear, an NAD(P)H oxidase appears to be involved. In smooth muscle, p22phox and 2 homologues of gp91phox, nox1 and nox4, are expressed, whereas fibroblasts contain gp91phox. To begin investigating the possibility that these oxidase components might contribute to the increased O2·- that accompanies neointimal formation, we measured their expression after balloon injury of the rat carotid artery. The increase in O2·- production 3 to 15 days after surgery was not due to inflammatory cell infiltration but appeared to be derived from medial and neointimal smooth muscle cells and adventitial fibroblasts. Nox1 and p22phox mRNAs were increased 2.7- and 3.6-fold, respectively, at day 3 after injury and remained elevated for 15 days. gp91Phox was increased 7 to 15 days after injury, and nox4 expression was increased 2-fold, but only at day 15 after surgery. These results confirm and extend our previous in vitro data and suggest that in the vasculature, the nox-based NAD(P)H oxidases serve different functions. This dynamic regulation of oxidase components may be critical to smooth muscle phenotypic modulation in restenosis and atherosclerosis.
Key Words: neointimal formation • superoxide • NAD(P)H oxidase • balloon injury • nox
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E. L. Schiffrin and R. M. Touyz From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H435 - H446. [Full Text] [PDF]
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C. Zhang, J. Yang, and L. K. Jennings Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H659 - H666. [Abstract] [Full Text] [PDF]
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P. C. Schulze, J. Yoshioka, T. Takahashi, Z. He, G. L. King, and R. T. Lee Hyperglycemia Promotes Oxidative Stress through Inhibition of Thioredoxin Function by Thioredoxin-interacting Protein J. Biol. Chem., July 16, 2004; 279(29): 30369 - 30374. [Abstract] [Full Text] [PDF]
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C. Taille, J. El-Benna, S. Lanone, M.-C. Dang, E. Ogier-Denis, M. Aubier, and J. Boczkowski Induction of Heme Oxygenase-1 Inhibits NAD(P)H Oxidase Activity by Down-regulating Cytochrome b558 Expression via the Reduction of Heme Availability J. Biol. Chem., July 2, 2004; 279(27): 28681 - 28688. [Abstract] [Full Text] [PDF]
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D. Zhuang, A.-C. Ceacareanu, Y. Lin, B. Ceacareanu, M. Dixit, K. E. Chapman, C. M. Waters, G. N. Rao, and A. Hassid Nitric oxide attenuates insulin- or IGF-I-stimulated aortic smooth muscle cell motility by decreasing H2O2 levels: essential role of cGMP Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2103 - H2112. [Abstract] [Full Text] [PDF]
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D. S. Weber, Y. Taniyama, P. Rocic, P. N. Seshiah, M. A. Dechert, W. T. Gerthoffer, and K. K. Griendling Phosphoinositide-Dependent Kinase 1 and p21-Activated Protein Kinase Mediate Reactive Oxygen Species-Dependent Regulation of Platelet-Derived Growth Factor-Induced Smooth Muscle Cell Migration Circ. Res., May 14, 2004; 94(9): 1219 - 1226. [Abstract] [Full Text] [PDF]
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J. D. van Buul and P. L. Hordijk Signaling in Leukocyte Transendothelial Migration Arterioscler Thromb Vasc Biol, May 1, 2004; 24(5): 824 - 833. [Abstract] [Full Text]
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T. Shiuchi, M. Iwai, H.-S. Li, L. Wu, L.-J. Min, J.-M. Li, M. Okumura, T.-X. Cui, and M. Horiuchi Angiotensin II Type-1 Receptor Blocker Valsartan Enhances Insulin Sensitivity in Skeletal Muscles of Diabetic Mice Hypertension, May 1, 2004; 43(5): 1003 - 1010. [Abstract] [Full Text] [PDF]
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L. L. Hilenski, R. E. Clempus, M. T. Quinn, J. D. Lambeth, and K. K. Griendling Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol, April 1, 2004; 24(4): 677 - 683. [Abstract] [Full Text] [PDF]
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G. A. Kaysen and J. P. Eiserich The Role of Oxidative Stress-Altered Lipoprotein Structure and Function and Microinflammation on Cardiovascular Risk in Patients with Minor Renal Dysfunction J. Am. Soc. Nephrol., March 1, 2004; 15(3): 538 - 548. [Abstract] [Full Text] [PDF]
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G. Cheng and J. D. Lambeth NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain J. Biol. Chem., February 6, 2004; 279(6): 4737 - 4742. [Abstract] [Full Text] [PDF]
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T. Jinno, M. Iwai, Z. Li, J.-M. Li, H.-W. Liu, T.-X. Cui, H. Rakugi, T. Ogihara, and M. Horiuchi Calcium Channel Blocker Azelnidipine Enhances Vascular Protective Effects of AT1 Receptor Blocker Olmesartan Hypertension, February 1, 2004; 43(2): 263 - 269. [Abstract] [Full Text] [PDF]
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T. Ago, T. Kitazono, H. Ooboshi, T. Iyama, Y. H. Han, J. Takada, M. Wakisaka, S. Ibayashi, H. Utsumi, and M. Iida Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H Oxidase Circulation, January 20, 2004; 109(2): 227 - 233. [Abstract] [Full Text] [PDF]
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T. Bleeke, H. Zhang, N. Madamanchi, C. Patterson, and J. E. Faber Catecholamine-Induced Vascular Wall Growth Is Dependent on Generation of Reactive Oxygen Species Circ. Res., January 9, 2004; 94(1): 37 - 45. [Abstract] [Full Text] [PDF]
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J. Hwang, M. H. Ing, A. Salazar, B. Lassegue, K. Griendling, M. Navab, A. Sevanian, and T. K. Hsiai Pulsatile Versus Oscillatory Shear Stress Regulates NADPH Oxidase Subunit Expression: Implication for Native LDL Oxidation Circ. Res., December 12, 2003; 93(12): 1225 - 1232. [Abstract] [Full Text] [PDF]
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R. P. Brandes Out of Balance: A Role of Impaired Superoxide Dismutase Activity for Vascular Constrictive Remodeling After Angioplasty Arterioscler Thromb Vasc Biol, December 1, 2003; 23(12): 2121 - 2122. [Full Text] [PDF]
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P. F. Leite, A. Danilovic, P. Moriel, K. Dantas, S. Marklund, A. P. V. Dantas, and F. R.M. Laurindo Sustained Decrease in Superoxide Dismutase Activity Underlies Constrictive Remodeling After Balloon Injury in Rabbits Arterioscler Thromb Vasc Biol, December 1, 2003; 23(12): 2197 - 2202. [Abstract] [Full Text] [PDF]
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Y. Taniyama and K. K. Griendling Reactive Oxygen Species in the Vasculature: Molecular and Cellular Mechanisms Hypertension, December 1, 2003; 42(6): 1075 - 1081. [Abstract] [Full Text] [PDF]
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J. Hwang, A. Saha, Y. C. Boo, G. P. Sorescu, J. S. McNally, S. M. Holland, S. Dikalov, D. P. Giddens, K. K. Griendling, D. G. Harrison, et al. Oscillatory Shear Stress Stimulates Endothelial Production of O2- from p47phox-dependent NAD(P)H Oxidases, Leading to Monocyte Adhesion J. Biol. Chem., November 21, 2003; 278(47): 47291 - 47298. [Abstract] [Full Text] [PDF]
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K. K. Griendling and G. A. FitzGerald Oxidative Stress and Cardiovascular Injury: Part II: Animal and Human Studies Circulation, October 28, 2003; 108(17): 2034 - 2040. [Full Text] [PDF]
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D. Gregg, F. M. Rauscher, and P. J. Goldschmidt-Clermont Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch Am J Physiol Cell Physiol, October 1, 2003; 285(4): C723 - C734. [Abstract] [Full Text] [PDF]
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M. E. Cifuentes and P. J. Pagano c-Src and Smooth Muscle NAD(P)H Oxidase: Assembling a Path to Hypertrophy Arterioscler Thromb Vasc Biol, June 1, 2003; 23(6): 919 - 921. [Full Text] [PDF]
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R. P. Brandes A Radical Adventure: The Quest for Specific Functions and Inhibitors of Vascular NAPDH Oxidases Circ. Res., April 4, 2003; 92(6): 583 - 585. [Full Text] [PDF]
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G. M. Jacobson, H. M. Dourron, J. Liu, O. A. Carretero, D. J. Reddy, T. Andrzejewski, and P. J. Pagano Novel NAD(P)H Oxidase Inhibitor Suppresses Angioplasty-Induced Superoxide and Neointimal Hyperplasia of Rat Carotid Artery Circ. Res., April 4, 2003; 92(6): 637 - 643. [Abstract] [Full Text] [PDF]
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Z. Ungvari, A. Csiszar, J. G. Edwards, P. M. Kaminski, M. S. Wolin, G. Kaley, and A. Koller Increased Superoxide Production in Coronary Arteries in Hyperhomocysteinemia: Role of Tumor Necrosis Factor-{alpha}, NAD(P)H Oxidase, and Inducible Nitric Oxide Synthase Arterioscler Thromb Vasc Biol, March 1, 2003; 23(3): 418 - 424. [Abstract] [Full Text] [PDF]
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F. E. Rey and P. J. Pagano The Reactive Adventitia: Fibroblast Oxidase in Vascular Function Arterioscler Thromb Vasc Biol, December 1, 2002; 22(12): 1962 - 1971. [Abstract] [Full Text] [PDF]
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K. M. Channon Oxidative Stress and Coronary Plaque Stability Arterioscler Thromb Vasc Biol, November 1, 2002; 22(11): 1751 - 1752. [Full Text] [PDF]
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N. L. Weintraub Nox Response to Injury Arterioscler Thromb Vasc Biol, January 1, 2002; 22(1): 4 - 5. [Full Text] [PDF]
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D. Sorescu, D. Weiss, B. Lassegue, R. E. Clempus, K. Szocs, G. P. Sorescu, L. Valppu, M. T. Quinn, J. D. Lambeth, J. D. Vega, et al. Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis Circulation, March 26, 2002; 105(12): 1429 - 1435. [Abstract] [Full Text] [PDF]
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