© 2001 American Heart Association, Inc.
Vascular Biology |
Network of Vascular-Associated Dendritic Cells in Intima of Healthy Young Individuals
From the Institute for Biomedical Aging Research, Austrian Academy of Sciences (G.M., G.W.), and the Institute for General and Experimental Pathology (G.M., H.N., G.W.), the Department of Forensic Medicine (W.R.), the Department of Transplant Surgery (B.W.H.), the Department of Cardiac Surgery (D.H.), and the Department of Dermatology (N.R.), University of Innsbruck, Innsbruck, Austria.
Correspondence to Georg Wick, MD, Institute for General and Experimental Pathology, Fritz-Pregl-Strasse 3, 6020 Innsbruck, Austria. E-mail Georg.Wick{at}uibk.ac.at
Abstract—In earlier studies, our group has established a new "immunological" hypothesis for atherogenesis supported by experimental and clinical studies showing that inflammatory immunological reactions against heat shock protein 60 initiate the development of atherosclerosis. In the present study, we describe the discovery of a so-far-unknown network of dendritic cells in the innermost layer of arteries, the intima, but not veins of healthy humans and rabbits. The number of these dendritic cells is comparable to that of Langerhans cells in the skin, and dendritic cells show a similar phenotype (CD1a+ S-100+ lag+ CD31- CD83- CD86- and no staining for von Willebrand factor or smooth muscle cell myosin). These vascular-associated dendritic cells accumulate most densely in those arterial regions that are subjected to major hemodynamic stress by turbulent flow conditions and are known to be predisposed for the later development of atherosclerosis. These results open new perspectives for the activation of the immune system within the arterial wall.
Key Words: atherosclerosis • intima • arteries • immunofluorescence • dendritic cells
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