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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2001;21:1969.)
© 2001 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Genome-Wide Linkage Analysis of Lipids in the Hypertension Genetic Epidemiology Network (HyperGEN) Blood Pressure Study

Hilary Coon; Mark F. Leppert; John H. Eckfeldt; Albert Oberman; Richard H. Myers; James M. Peacock; Michael A. Province; Paul N. Hopkins; Gerardo Heiss

From the Department of Psychiatry (H.C.), the Department of Human Genetics (M.F.L.), and Cardiovascular Genetics, Department of Internal Medicine (P.N.H.), University of Utah, Salt Lake City; the Department of Laboratory Medicine and Pathology (J.H.E.), Medical School, and the Division of Epidemiology (J.M.P.), School of Public Health, University of Minnesota, Minneapolis; the Division of Preventive Medicine (A.O.), Department of Medicine, University of Alabama at Birmingham; the Section of Preventive Medicine and Epidemiology (R.H.M.), Boston University School of Medicine, Boston, Mass; the Division of Biostatistics (M.A.P.), Washington University Medical School, St. Louis, Mo; and the Department of Epidemiology (G.H.), University of North Carolina, Chapel Hill.

Correspondence to Hilary Coon, Utah Neurodevelopmental Genetics Project, Red Butte Health Center Suite 442, 546 Chipeta Way, Salt Lake City, UT 84108. E-mail hilary{at}wilbur.med.utah.edu

Full genome scans were performed for quantitative lipid measurements in 622 African American and 649 white sibling pairs not taking lipid-lowering medications who were ascertained through the Hypertension Genetic Epidemiology Network (HyperGEN) of the National Heart, Lung, and Blood Institute (NHLBI) Family Blood Pressure Program. Genotypes for 391 markers spaced roughly equally throughout the genome were typed by the NHLBI Mammalian Genotyping Service. Each of the phenotypes was adjusted for covariates within sex and race and then subjected to variance components linkage analysis, which was performed separately within race by using race-specific marker allele frequencies from additional random samples. The highest lod score detected was 2.77 for logarithmically transformed triglyceride (TG) on chromosome 20 (at 28.6 cM) in the African American sibling pairs. The highest score detected in the white sibling pairs was 2.74 for high density lipoprotein cholesterol on chromosome 5 (at 48.2 cM). Although no scores >3.0 were obtained, positive scores were found in several regions that have been reported in other genome scans in the literature. For example, a score of 1.91 for TG was found on chromosome 15 (at 28.8 cM) in white sibling pairs. This score overlaps the positive findings for TG in 2 other genome scans.

Key Words: genome scan • lipids • cholesterol • triglyceride • genetic linkage

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