Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:2094-2099
© 2000 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
C-Reactive Protein in the Arterial Intima
Role of C-Reactive Protein Receptor–Dependent Monocyte Recruitment in Atherogenesis
From the Institute of Clinical Chemistry and Laboratory Medicine (M.T., G.S.), University of Regensburg, Regensburg, Germany; the Department of Microbiology (R.F.M.), The Ohio State University, Columbus; and the Department of Internal Medicine II (C.R., T.P.Z., M.B., J.W., W.K., V.H., J.T.), Cardiology, University of Ulm, Ulm, Germany.
Correspondence to Dr Jan Torzewski, University of Ulm, Department of Internal Medicine II, Cardiology, Robert Koch-Str. 8, 89081 Ulm, Germany. E-mail Jan.Torzewski{at}medizin.uni-ulm.de
Abstract—Infiltration of monocytes into the arterial wall is an early cellular event in atherogenesis. Recent evidence shows that C-reactive protein (CRP) is deposited in the arterial intima at sites of atherogenesis. In this study, we demonstrate that CRP deposition precedes the appearance of monocytes in early atherosclerotic lesions. CRP is chemotactic for freshly isolated human blood monocytes. A specific CRP receptor is demonstrated on monocytes in vitro as well as in vivo, and blockage of the receptor by use of a monoclonal anti-receptor antibody completely abolishes CRP-induced chemotaxis. CRP may play a major role in the recruitment of monocytes during atherogenesis.
Key Words: C-reactive proteins • C-reactive protein receptors • monocytes • chemotaxis • atherogenesis
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