Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:2032-2037
© 2000 American Heart Association, Inc.
Brief Review |
Does ADMA Cause Endothelial Dysfunction?
From the Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, Calif.
Correspondence to John P. Cooke, MD, PhD, Associate Professor and Director, Section of Vascular Medicine, Division of Cardiovascular Medicine, CVRC, Falk Cardiovascular Research Center, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305-5406. E-mail john.cooke{at}stanford.edu
Abstract—Asymmetric dimethylarginine (ADMA) is an endogenous and competitive inhibitor of nitric oxide synthase. Plasma levels of this inhibitor are elevated in patients with atherosclerosis and in those with risk factors for atherosclerosis. In these patients, plasma ADMA levels are correlated with the severity of endothelial dysfunction and atherosclerosis. By inhibiting the production of nitric oxide, ADMA may impair blood flow, accelerate atherogenesis, and interfere with angiogenesis. ADMA may be a novel risk factor for vascular disease.
Key Words: arginine • nitric oxide • atherosclerosis • vasodilation
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